Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase.
about
Functional analysis of Tpr: identification of nuclear pore complex association and nuclear localization domains and a role in mRNA exportAssociation of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6Amino acid substitutions of coiled-coil protein Tpr abrogate anchorage to the nuclear pore complex but not parallel, in-register homodimerizationLigand-regulated binding of FAP68 to the hepatocyte growth factor receptorUse of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasisThe DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domainAssociation of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cellsRole of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesisA family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptorCharacterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastomaThe MET axis as a therapeutic target.Enhanced signaling and morphological transformation by a membrane-localized derivative of the fibroblast growth factor receptor 3 kinase domainBiology of MET: a double life between normal tissue repair and tumor progressionTpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complexMet receptor tyrosine kinase: enhanced signaling through adapter proteinsFGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndromeNormal and malignant prostate epithelial cells differ in their response to hepatocyte growth factor/scatter factorCoupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responsesAssociation of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytesCrk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions.Activation of the JNK pathway is essential for transformation by the Met oncogeneMutation-introduced dimerization of receptor tyrosine kinases: from protein structure aberrations to carcinogenesis.Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma.A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein.Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-gamma2 by the M-CSF receptor is necessary for differentiation signalingEnhanced transformation by a plasma membrane-associated met oncoprotein: activation of a phosphoinositide 3'-kinase-dependent autocrine loop involving hyaluronic acid and CD44.Translocations involving anaplastic lymphoma kinase (ALK).Constitutive activation of MET signaling impairs myogenic differentiation of rhabdomyosarcoma and promotes its development and progression.Dysregulation of Met receptor tyrosine kinase activity in invasive tumorsRole of the nuclear envelope in genome organization and gene expression.Gab1 is required for cell cycle transition, cell proliferation, and transformation induced by an oncogenic met receptor.The role of the c-Met pathway in lung cancer and the potential for targeted therapy.CD44 is required for two consecutive steps in HGF/c-Met signaling.Transforming activity of retroviral genomes encoding Gag-Axl fusion proteins.Targeting the HGF/c-MET pathway in hepatocellular carcinoma.The C. elegans Discoidin Domain Receptor DDR-2 Modulates the Met-like RTK-JNK Signaling Pathway in Axon RegenerationConstitutive activation of the RON gene promotes invasive growth but not transformation.c-Met and hepatocyte growth factor: potential as novel targets in cancer therapy.The mutationally activated Met receptor mediates motility and metastasis.
P2860
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P2860
Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase.
description
1993 nî lūn-bûn
@nan
1993 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Dimerization mediated through ...... met receptor tyrosine kinase.
@ast
Dimerization mediated through ...... met receptor tyrosine kinase.
@en
Dimerization mediated through ...... met receptor tyrosine kinase.
@nl
type
label
Dimerization mediated through ...... met receptor tyrosine kinase.
@ast
Dimerization mediated through ...... met receptor tyrosine kinase.
@en
Dimerization mediated through ...... met receptor tyrosine kinase.
@nl
prefLabel
Dimerization mediated through ...... met receptor tyrosine kinase.
@ast
Dimerization mediated through ...... met receptor tyrosine kinase.
@en
Dimerization mediated through ...... met receptor tyrosine kinase.
@nl
P2860
P356
P1476
Dimerization mediated through ...... met receptor tyrosine kinase.
@en
P2093
P2860
P304
P356
10.1128/MCB.13.11.6711
P407
P577
1993-11-01T00:00:00Z