A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites.
about
Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cellsRepression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factorsTherapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificitiesToward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocksA rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoterPositive and negative regulation of endogenous genes by designed transcription factorsRapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modificationTargeted genome editing in human cells with zinc finger nucleases constructed via modular assemblyToward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequencesDesign of polydactyl zinc-finger proteins for unique addressing within complex genomesA bacterial two-hybrid selection system for studying protein-DNA and protein-protein interactionsHighly specific zinc finger proteins obtained by directed domain shuffling and cell-based selectionSuppression of vascular endothelial growth factor expression at the transcriptional and post-transcriptional levels.Genome Engineering with TALE and CRISPR Systems in NeuroscienceOrigins of Programmable Nucleases for Genome EngineeringFrom Gene Targeting to Genome Editing: Transgenic animals applications and beyondProtein design: toward functional metalloenzymesDomain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIADiffering roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complexMassively parallel measurements of molecular interaction kinetics on a microfluidic platform.Site-selective in vivo targeting of cytosine-5 DNA methylation by zinc-finger proteinsDevelopment of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factorsUnconventional potentiation of gene expression by IkarosEngineering polydactyl zinc-finger transcription factorsConcerted evolution of structure and function in a miniature proteinEvolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genesHoming endonucleases: structural and functional insight into the catalysts of intron/intein mobilitySelection of catalytically active biotin ligase and trypsin mutants by phage display.Investigating and Engineering Enzymes by Genetic Selection.Human zinc fingers as building blocks in the construction of artificial transcription factors.A phage display selection of engrailed homeodomain mutants and the importance of residue Q50.Structure based design of protein linkers for zinc finger nuclease.Phenotypic alteration of eukaryotic cells using randomized libraries of artificial transcription factors.Optimizing the affinity and specificity of proteins with molecular display.Profiling the DNA-binding specificities of engineered Cys2His2 zinc finger domains using a rapid cell-based methodTailor-made zinc-finger transcription factors activate FLO11 gene expression with phenotypic consequences in the yeast Saccharomyces cerevisiae.Phenotypic engineering by reprogramming gene transcription using novel artificial transcription factors in Escherichia coliRapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN).Positive selection of DNA-protein interactions in mammalian cells through phenotypic coupling with retrovirus production.Experimental determination of the evolvability of a transcription factor.
P2860
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P2860
A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites.
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
A general strategy for selecti ...... for diverse DNA target sites.
@ast
A general strategy for selecti ...... for diverse DNA target sites.
@en
A general strategy for selecti ...... for diverse DNA target sites.
@nl
type
label
A general strategy for selecti ...... for diverse DNA target sites.
@ast
A general strategy for selecti ...... for diverse DNA target sites.
@en
A general strategy for selecti ...... for diverse DNA target sites.
@nl
prefLabel
A general strategy for selecti ...... for diverse DNA target sites.
@ast
A general strategy for selecti ...... for diverse DNA target sites.
@en
A general strategy for selecti ...... for diverse DNA target sites.
@nl
P1433
P1476
A general strategy for selecti ...... for diverse DNA target sites.
@en
P2093
P304
P356
10.1126/SCIENCE.275.5300.657
P407
P577
1997-01-01T00:00:00Z