Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations. - Wikidata - awgldk - TriplyDB

Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.

Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.

http://www.wikidata.org/entity/Q34452296

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Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation Inhibition of LRRK2 kinase activity stimulates macroautophagy Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models ERKed by LRRK2: a cell biological perspective on hereditary and sporadic Parkinson's disease.Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.RNA metabolism in the pathogenesis of Parkinson׳s disease Decoding Parkinson's Disease Pathogenesis: The Role of Deregulated mRNA Translation.Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases.LRRK2 pathobiology in Parkinson's disease.Cellular processes associated with LRRK2 function and dysfunction LRRK2 Kinase Inhibition as a Therapeutic Strategy for Parkinson's Disease, Where Do We Stand?Abberant protein synthesis in G2019S LRRK2 Drosophila Parkinson disease-related phenotypes.Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells.Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.The LRRK2 signalling system.Effect of leucine-rich repeat kinase 2 (LRRK2) on protein synthesis

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P2860

Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.

http://www.wikidata.org/entity/Q34452296

description

2012 nî lūn-bûn

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2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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Phosphorylation of 4E-BP1 in t ...... ssion or pathogenic mutations.

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Phosphorylation of 4E-BP1 in t ...... ssion or pathogenic mutations.

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Phosphorylation of 4E-BP1 in t ...... ssion or pathogenic mutations.

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Phosphorylation of 4E-BP1 in t ...... ssion or pathogenic mutations.

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Phosphorylation of 4E-BP1 in t ...... ssion or pathogenic mutations.

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Phosphorylation of 4E-BP1 in t ...... ssion or pathogenic mutations.

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Phosphorylation of 4E-BP1 in t ...... ssion or pathogenic mutations.

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Phosphorylation of 4E-BP1 in t ...... ssion or pathogenic mutations.

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Phosphorylation of 4E-BP1 in t ...... ssion or pathogenic mutations.

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Phosphorylation of 4E-BP1 in t ...... ssion or pathogenic mutations.

@en

P2093

Adamantios Mamais

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Alzbeta Trancikova

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Andrew B West

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Darren J Moore

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Elpida Tsika

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Klodjan Stafa

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Liliane Glauser

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Philip J Webber

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Rina Bandopadhyay

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P2860

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

Kinase activity of mutant LRRK2 mediates neuronal toxicity

ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

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phosphorylation

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