about
Complex Loci in human and mouse genomesHuman SAD1 kinase is involved in UV-induced DNA damage checkpoint functionThe human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machineryFunctional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free systemDisruption of mechanisms that prevent rereplication triggers a DNA damage responseLoss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damageHuman Claspin works with BRCA1 to both positively and negatively regulate cell proliferationThe ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair responseKruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damageThe human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilonFission yeast Rad26 responds to DNA damage independently of Rad3Evolutionary clues to eukaryotic DNA clamp-loading mechanisms: analysis of the functional constraints imposed on replication factor C AAA+ ATPasesSex-dependent gene expression in early brain development of chicken embryos.Bub3-BubR1-dependent sequestration of Cdc20Fizzy at DNA breaks facilitates the correct segregation of broken chromosomesTimeless links replication termination to mitotic kinase activationStructural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repairUse of quantitative mass spectrometric analysis to elucidate the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo.The WTM genes in budding yeast amplify expression of the stress-inducible gene RNR3.The Rpd3-Sin3 histone deacetylase regulates replication timing and enables intra-S origin control in Saccharomyces cerevisiae.Spo13 regulates cohesin cleavage.The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1.CDK Pho85 targets CDK inhibitor Sic1 to relieve yeast G1 checkpoint arrest after DNA damage.Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint.Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint.Xbp1-mediated histone H4 deacetylation contributes to DNA double-strand break repair in yeast.Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitmentControl of the yeast telomeric senescence survival pathways of recombination by the Mec1 and Mec3 DNA damage sensors and RPA.S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex.Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex.NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damageHuman claspin is required for replication checkpoint controlNFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage responseNFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathwaysRecruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phase53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damage14-3-3 proteins--an updateCell death by mitotic catastrophe: a molecular definitionHuman claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structuresATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background
P2860
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P2860
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
A unified view of the DNA-damage checkpoint.
@ast
A unified view of the DNA-damage checkpoint.
@en
A unified view of the DNA-damage checkpoint.
@nl
type
label
A unified view of the DNA-damage checkpoint.
@ast
A unified view of the DNA-damage checkpoint.
@en
A unified view of the DNA-damage checkpoint.
@nl
prefLabel
A unified view of the DNA-damage checkpoint.
@ast
A unified view of the DNA-damage checkpoint.
@en
A unified view of the DNA-damage checkpoint.
@nl
P1476
A unified view of the DNA-damage checkpoint.
@en
P2093
David Toczyski
Justine Melo
P304
P356
10.1016/S0955-0674(02)00312-5
P577
2002-04-01T00:00:00Z