The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses.
about
Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes.Total synthesis of bryostatin 16 using a Pd-catalyzed diyne coupling as macrocyclization method and synthesis of C20-epi-bryostatin 7 as a potent anticancer agent.Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivityTotal synthesis of bryostatin 9Synthesis of seco-B-ring bryostatin analogue WN-1 via C-C bond-forming hydrogenation: critical contribution of the B-ring in determining bryostatin-like and phorbol 12-myristate 13-acetate-like properties.Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone coreTranslating Nature's Library: The Bryostatins and Function-Oriented SynthesisTotal synthesis of bryostatin 1The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell lineMechanistic and computational studies of exocyclic stereocontrol in the synthesis of bryostatin-like cis-2,6-disubstituted 4-alkylidenetetrahydropyrans by Prins cyclization.Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action.Probing the biology of natural products: molecular editing by diverted total synthesis.Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cδ.Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin.Structural insights into the interactions of phorbol ester and bryostatin complexed with protein kinase C: a comparative molecular dynamics simulation study.Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-like Biology.Replacement of the Bryostatin A- and B-Pyran Rings With Phenyl Rings Leads to Loss of High Affinity Binding With PKC.Syntheses of C17-C27 fragments of 20-deoxybryostatins for assembly using Julia and metathesis reactions.Total synthesis of 7-des-O-pivaloyl-7-O-benzylbryostatin 10.Synthetic approaches to the C11-C27 fragments of bryostatins.The evolution of a stereoselective synthesis of the C1-C16 fragment of bryostatins.Biological activity of the bryostatin analog Merle 23 on mouse epidermal cells and mouse skin.
P2860
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P2860
The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses.
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The bryostatin 1 A-ring acetat ...... -induced biological responses.
@ast
The bryostatin 1 A-ring acetat ...... -induced biological responses.
@en
The bryostatin 1 A-ring acetat ...... -induced biological responses.
@nl
type
label
The bryostatin 1 A-ring acetat ...... -induced biological responses.
@ast
The bryostatin 1 A-ring acetat ...... -induced biological responses.
@en
The bryostatin 1 A-ring acetat ...... -induced biological responses.
@nl
prefLabel
The bryostatin 1 A-ring acetat ...... -induced biological responses.
@ast
The bryostatin 1 A-ring acetat ...... -induced biological responses.
@en
The bryostatin 1 A-ring acetat ...... -induced biological responses.
@nl
P2093
P2860
P356
P1433
P1476
The bryostatin 1 A-ring acetat ...... -induced biological responses.
@en
P2093
Gary E Keck
Matthew B Kraft
Nancy E Lewin
Noemi Kedei
Peter M Blumberg
P2860
P304
P356
10.1021/OL900585T
P407
P577
2009-06-01T00:00:00Z