Metabolic targeting as an anticancer strategy: dawn of a new era?
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Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loopsDistinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicolAneuploidy: cancer's fatal flaw?Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growthRedox-directed cancer therapeutics: molecular mechanisms and opportunitiesDichloroacetate (DCA) as a potential metabolic-targeting therapy for cancerCardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancerReview of aerobic glycolysis and its key enzymes - new targets for lung cancer therapyTime and Circumstances: Cancer Cell Metabolism at Various Stages of Disease ProgressionRegulation and function of proline oxidase under nutrient stressMetabolic modulation of glioblastoma with dichloroacetateProfiling Y561-dependent and -independent substrates of CSF-1R in epithelial cellsMetabolic profiling reveals key metabolic features of renal cell carcinoma.Suppression of soft tissue sarcoma growth by a host defense-like lytic peptide.Energy metabolism during anchorage-independence. Induction by osteopontin-c.Dysregulation of the mevalonate pathway promotes transformationPhosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cellsCarnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress.Glycolytic metabolites are critical modulators of oocyte maturation and viabilityCancer as a dynamical phase transition.DCA promotes progression of neuroblastoma tumors in nude mice.AMPK-mediated energy homeostasis and associated metabolic effects on cancer cell response and resistance to cetuximab.The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogrammingThe PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation.Calicum microdomains form within neutrophils at the neutrophil-tumor cell synapse: role in antibody-dependent target cell apoptosisLoss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy.Pyruvate Dehydrogenase Kinases in the Nervous System: Their Principal Functions in Neuronal-glial Metabolic Interaction and Neuro-metabolic Disorders.Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression.Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors.Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation.Laforin confers cancer resistance to energy deprivation-induced apoptosis.PPARgamma and Proline Oxidase in Cancer.Metabolite profiling of human colon carcinoma--deregulation of TCA cycle and amino acid turnoverProteomic analysis of energy metabolism and signal transduction in irradiated melanoma cells.Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver.Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinomaAAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells.Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α.Inhibiting histone deacetylases suppresses glucose metabolism and hepatocellular carcinoma growth by restoring FBP1 expression.
P2860
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P2860
Metabolic targeting as an anticancer strategy: dawn of a new era?
description
2007 nî lūn-bûn
@nan
2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Metabolic targeting as an anticancer strategy: dawn of a new era?
@ast
Metabolic targeting as an anticancer strategy: dawn of a new era?
@en
Metabolic targeting as an anticancer strategy: dawn of a new era?
@nl
type
label
Metabolic targeting as an anticancer strategy: dawn of a new era?
@ast
Metabolic targeting as an anticancer strategy: dawn of a new era?
@en
Metabolic targeting as an anticancer strategy: dawn of a new era?
@nl
prefLabel
Metabolic targeting as an anticancer strategy: dawn of a new era?
@ast
Metabolic targeting as an anticancer strategy: dawn of a new era?
@en
Metabolic targeting as an anticancer strategy: dawn of a new era?
@nl
P356
P1476
Metabolic targeting as an anticancer strategy: dawn of a new era?
@en
P2093
James G Pan
P356
10.1126/STKE.3812007PE14
P577
2007-04-10T00:00:00Z