Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes. - Wikidata - awgldk - TriplyDB

Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes.

Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes.

http://www.wikidata.org/entity/Q34636910

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Unravelling the mechanism of action of NS9283, a positive allosteric modulator of (α4)3(β2)2 nicotinic ACh receptors α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum Structure-Function Elucidation of a New -Conotoxin, Lo1a, from Conus longurionis Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats Contrasting properties of α7-selective orthosteric and allosteric agonists examined on native nicotinic acetylcholine receptors Evaluating the role of the alpha-7 nicotinic acetylcholine receptor in the pathophysiology and treatment of schizophrenia.Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of α7 nicotinic acetylcholine receptors.Intrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperatures High throughput electrophysiology with Xenopus oocytes Physiological concentrations of choline activate native alpha7-containing nicotinic acetylcholine receptors in the presence of PNU-120596 [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea].ELIC-α7 Nicotinic acetylcholine receptor (α7nAChR) chimeras reveal a prominent role of the extracellular-transmembrane domain interface in allosteric modulation.Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection.Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596 In search of allosteric modulators of a7-nAChR by solvent density guided virtual screening.Pharmacological characterization of the allosteric modulator desformylflustrabromine and its interaction with alpha4beta2 neuronal nicotinic acetylcholine receptor orthosteric ligands.A new IRAK-M-mediated mechanism implicated in the anti-inflammatory effect of nicotine via α7 nicotinic receptors in human macrophages.Tethered agonist analogs as site-specific probes for domains of the human α7 nicotinic acetylcholine receptor that differentially regulate activation and desensitization.New Insights into the Mechanisms of Action of Cotinine and its Distinctive Effects from Nicotine.Function of partially duplicated human α77 nicotinic receptor subunit CHRFAM7A gene: potential implications for the cholinergic anti-inflammatory response.alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues.Structural answers and persistent questions about how nicotinic receptors work.Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.An allosteric modulator of alpha7 nicotinic receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine.Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects.Functional alpha7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus High therapeutic potential of positive allosteric modulation of α7 nAChRs in a rat model of traumatic brain injury: proof-of-concept Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations.Two novel α7 nicotinic acetylcholine receptor ligands: in vitro properties and their efficacy in collagen-induced arthritis in mice.Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation.Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states.Pharmacological characterization of native α7 nicotinic ACh receptors and their contribution to depolarization-elicited exocytosis in human chromaffin cells.The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors Potential state-selective hydrogen bond formation can modulate activation and desensitization of the α7 nicotinic acetylcholine receptor Sazetidine-A Activates and Desensitizes Native α7 Nicotinic Acetylcholine Receptors.A Novel α2/α4 Subtype-selective Positive Allosteric Modulator of Nicotinic Acetylcholine Receptors Acting from the C-tail of an α Subunit Activation of α7 nicotinic receptors by orthosteric and allosteric agonists: influence on single-channel kinetics and conductance Effects of α7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models.Dissection of N,N-diethyl-N'-phenylpiperazines as α7 nicotinic receptor silent agonists

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Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes.

http://www.wikidata.org/entity/Q34636910

description

2007 nî lūn-bûn

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2007 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2007 թվականի հունիսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Distinct profiles of alpha7 nA ...... ructurally diverse chemotypes.

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Distinct profiles of alpha7 nA ...... ructurally diverse chemotypes.

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Distinct profiles of alpha7 nA ...... ructurally diverse chemotypes.

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Distinct profiles of alpha7 nA ...... ructurally diverse chemotypes.

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Distinct profiles of alpha7 nA ...... ructurally diverse chemotypes.

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Distinct profiles of alpha7 nA ...... ructurally diverse chemotypes.

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Distinct profiles of alpha7 nA ...... ructurally diverse chemotypes.

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Distinct profiles of alpha7 nA ...... ructurally diverse chemotypes.

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Distinct profiles of alpha7 nA ...... ructurally diverse chemotypes.

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Molecular Pharmacology

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Distinct profiles of alpha7 nA ...... ructurally diverse chemotypes.

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Clark A Briggs

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Hilde Ween

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Jens Halvard Grønlien

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John Malysz

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Kirsten Thorin-Hagene

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Monika Håkerud

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Murali Gopalakrishnan

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715-724

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scholarly article

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10.1124/MOL.107.035410

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3

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72

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2007-06-12T00:00:00Z

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6272068

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17565004

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