The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. - Wikidata - awgldk - TriplyDB

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

http://www.wikidata.org/entity/Q34762767

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Fundamentals of cancer metabolism Evolving Insights on Metabolism, Autophagy, and Epigenetics in Liver Myofibroblasts MicroRNAs and oncogenic transcriptional regulatory networks controlling metabolic reprogramming in cancers Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?Targeting mitochondria metabolism for cancer therapy Defects in mitochondrial metabolism and cancer Oncometabolites: Unconventional triggers of oncogenic signalling cascades Caveolin-1 in the regulation of cell metabolism: a cancer perspective Sending Out an SOS: Mitochondria as a Signaling Hub Changing perspective on oncometabolites: from metabolic signature of cancer to tumorigenic and immunosuppressive agents Role of mitochondrial dysfunction in cancer progression Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions ROS function in redox signaling and oxidative stress Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis Molecular markers of paragangliomas/pheochromocytomas Overexpression of the human DEK oncogene reprograms cellular metabolism and promotes glycolysis The oncometabolite fumarate promotes pseudohypoxia through noncanonical activation of NF-κB signaling The Succinated Proteome of FH-Mutant Tumours Oncometabolites: linking altered metabolism with cancer.Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2.Identification of fumarate hydratase inhibitors with nutrient-dependent cytotoxicity.Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.Fumarate induces redox-dependent senescence by modifying glutathione metabolism.Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer.DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells Emerging regulatory paradigms in glutathione metabolism.Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype.TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein The Mitochondrial Respiratory Chain Is Required for Organismal Adaptation to Hypoxia.Complex role of HIF in cancer: the known, the unknown, and the unexpected.Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition Cancer cell metabolism and the modulating effects of nitric oxide.Metabostemness: a new cancer hallmark.ROS and energy metabolism in cancer cells: alliance for fast growth.Targeting T cell metabolism for therapy.Mitochondrial reactive oxygen species and cancer.Expanding roles of superoxide dismutases in cell regulation and cancer The emerging role and targetability of the TCA cycle in cancer metabolism.Gerometabolites: the pseudohypoxic aging side of cancer oncometabolites.

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P2860

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

http://www.wikidata.org/entity/Q34762767

description

2013 nî lūn-bûn

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2013 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2013 թվականի հունիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

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name

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

@ast

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

@en

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

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type

label

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

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The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

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The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

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prefLabel

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

@ast

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

@en

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

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P356

J.MOLCEL.2013.05.003

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P1476

The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling

@en

P2093

Andrew R Mullen

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Eva Martinez-Garcia

http://www.w3.org/2001/XMLSchema#string

Hien Nguyen

http://www.w3.org/2001/XMLSchema#string

Jonathan D Licht

http://www.w3.org/2001/XMLSchema#string

Navdeep S Chandel

http://www.w3.org/2001/XMLSchema#string

Ralph J Deberardinis

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Sunil Sudarshan

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P2860

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers

Hypoxia-inducible factors in physiology and medicine

On the Origin of Cancer Cells

Regulation of cancer cell metabolism

Reduced expression of fumarate hydratase in clear cell renal cancer mediates HIF-2α accumulation and promotes migration and invasion

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

Aerobic glycolysis: meeting the metabolic requirements of cell proliferation

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

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236-248

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scholarly article

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10.1016/J.MOLCEL.2013.05.003

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2

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51

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Lucas B Sullivan

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2013-06-06T00:00:00Z

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237083446

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23747014

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3775267

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