Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets.
about
Molecular topology as novel strategy for discovery of drugs with aβ lowering and anti-aggregation dual activities for Alzheimer's diseaseProgressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteinsTherapeutic benefits of a component of coffee in a rat model of Alzheimer's disease.Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanismValsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer diseaseNovel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease.Mechanisms of amyloid formation revealed by solution NMRNeuropathological alterations in Alzheimer diseaseStructural evolution and membrane interactions of Alzheimer's amyloid-beta peptide oligomers: new knowledge from single-molecule fluorescence studiesAmyloid-Beta Induced Changes in Vesicular Transport of BDNF in Hippocampal NeuronsHMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease.Molecular basis of -amyloid oligomer recognition with a conformational antibody fragmentAPOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspectiveDisruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid betaStability and structure of oligomers of the Alzheimer peptide Abeta16-22: from the dimer to the 32-merA new target for amyloid beta toxicity validated by standard and high-throughput electrophysiologyAlzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficitsNanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aβ Oligomers.Identification of a Novel Parallel β-Strand Conformation within Molecular Monolayer of Amyloid PeptideImpaired balance of mitochondrial fission and fusion in Alzheimer's diseaseAlzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicityNeuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's diseaseTrafficking of glucose, lactate, and amyloid-beta from the inferior colliculus through perivascular routes.Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse modelCystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease.Carvedilol as a potential novel agent for the treatment of Alzheimer's disease.Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosisDeleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5Pivotal role of the RanBP9-cofilin pathway in Aβ-induced apoptosis and neurodegeneration.Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's diseaseNeurotoxic amyloid beta oligomeric assemblies recreated in microfluidic platform with interstitial level of slow flowThe Armc10/SVH gene: genome context, regulation of mitochondrial dynamics and protection against Aβ-induced mitochondrial fragmentationFingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal NeuronsExpression and localization of mitochondrial ferritin mRNA in Alzheimer's disease cerebral cortex.Role of glutathione in intracellular amyloid-alpha precursor protein/carboxy-terminal fragment aggregation and associated cytotoxicity.Amelioration of amyloid load by anti-Abeta single-chain antibody in Alzheimer mouse modelQuartz crystal microbalance studies of multilayer glucagon fibrillation at the solid-liquid interfaceMitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDsDetection and Identification of Bioanalytes with High Resolution LSPR Spectroscopy and MALDI Mass Spectrometry.
P2860
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P2860
Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets.
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Abeta toxicity in Alzheimer's ...... new vaccine and drug targets.
@ast
Abeta toxicity in Alzheimer's ...... new vaccine and drug targets.
@en
Abeta toxicity in Alzheimer's disease: globular oligomers
@nl
type
label
Abeta toxicity in Alzheimer's ...... new vaccine and drug targets.
@ast
Abeta toxicity in Alzheimer's ...... new vaccine and drug targets.
@en
Abeta toxicity in Alzheimer's disease: globular oligomers
@nl
prefLabel
Abeta toxicity in Alzheimer's ...... new vaccine and drug targets.
@ast
Abeta toxicity in Alzheimer's ...... new vaccine and drug targets.
@en
Abeta toxicity in Alzheimer's disease: globular oligomers
@nl
P1476
Abeta toxicity in Alzheimer's ...... new vaccine and drug targets.
@en
P2093
William L Klein
P304
P356
10.1016/S0197-0186(02)00050-5
P577
2002-11-01T00:00:00Z