AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer - Wikidata - awgldk - TriplyDB

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

http://www.wikidata.org/entity/Q34990362

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Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation A novel regulatory mechanism links PLCγ1 to PDK1 Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions A YKL-40-neutralizing antibody blocks tumor angiogenesis and progression: a potential therapeutic agent in cancers Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy The PI3K pathway as drug target in human cancer Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy Targeting the PI3K signaling pathway in cancer Novel drugs that target the metabolic reprogramming in renal cell cancer Interactions between Trypanosoma cruzi Secreted Proteins and Host Cell Signaling Pathways Pharmacodynamic Biomarker Development for PI3K Pathway Therapeutics MEK and PI3K inhibition in solid tumors: rationale and evidence to date PI3K and AKT: Unfaithful Partners in Cancer mTOR-dependent cell survival mechanisms Genetic and Pharmacological Inhibition of PDK1 in Cancer Cells: CHARACTERIZATION OF A SELECTIVE ALLOSTERIC KINASE INHIBITOR Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors.PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition mTOR signaling in tumorigenesis Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set Genotype directed therapy in murine mismatch repair deficient tumors Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases E-cadherin-mediated force transduction signals regulate global cell mechanics Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase.Colocalized delivery of rapamycin and paclitaxel to tumors enhances synergistic targeting of the PI3K/Akt/mTOR pathway.BAYESIAN SPARSE GRAPHICAL MODELS FOR CLASSIFICATION WITH APPLICATION TO PROTEIN EXPRESSION DATA.mTOR and cancer: many loops in one pathway.c-Jun regulates phosphoinositide-dependent kinase 1 transcription: implication for Akt and protein kinase C activities and melanoma tumorigenesis Systematic analysis of genotype-specific drug responses in cancer.Timp1 Promotes Cell Survival by Activating the PDK1 Signaling Pathway in Melanoma.Reverse-phase protein array profiling of oropharyngeal cancer and significance of PIK3CA mutations in HPV-associated head and neck cancer.Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.SGK3 is an androgen-inducible kinase promoting prostate cancer cell proliferation through activation of p70 S6 kinase and up-regulation of cyclin D1.Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains.

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AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

http://www.wikidata.org/entity/Q34990362

description

2009 nî lūn-bûn

@nan

2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հուլիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

@ast

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

@en

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

@nl

type

label

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

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AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

@en

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

@nl

prefLabel

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

@ast

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

@en

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

@nl

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J.CCR.2009.04.012

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AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

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Ana Lluch

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Ana Maria Gonzalez-Angulo

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Anna C Schinzel

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Aysegul A Sahin

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Bhaskar Dutta

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Bryan T Hennessy

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Chontelle J McNear

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Corwin Joy

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David A Barbie

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David E Root

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P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

The PI3K-PDK1 connection: more than just a road to PKB

A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

Knockin of mutant PIK3CA activates multiple oncogenic pathways

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21-32

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scholarly article

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10.1016/J.CCR.2009.04.012

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1

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16

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Katherine Stemke-Hale

Levi A Garraway

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2009-07-01T00:00:00Z

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26337316

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19573809

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2752826

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