Mode of action in relevance of rodent liver tumors to human cancer risk.
about
Phenobarbital induces alterations in the proteome of hepatocytes and mesenchymal cells of rat liversCritical role of toxicologic pathology in a short-term screen for carcinogenicityGenomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of actionImpact of Genomics Platform and Statistical Filtering on Transcriptional Benchmark Doses (BMD) and Multiple Approaches for Selection of Chemical Point of Departure (PoD)A review of the molecular mechanisms of chemically induced neoplasia in rat and mouse models in National Toxicology Program bioassays and their relevance to human cancerNon-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylomeScientific and Regulatory Policy Committee (SRPC) Review: Interpretation and Use of Cell Proliferation Data in Cancer Risk Assessment.A data-based assessment of alternative strategies for identification of potential human cancer hazards.The mouse carcinogenicity study is no longer a scientifically justifiable core data requirement for the safety assessment of pesticides.Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activatorPhenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive androstane receptor (CAR) activation plays in their mode of actionActivation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Evaluation of the carcinogenicity of inorganic arsenic.Data mining reveals a network of early-response genes as a consensus signature of drug-induced in vitro and in vivo toxicityXenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicitiesOrtho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes.Multi-species analyses of direct activators of the constitutive androstane receptor.Predicting the future: opportunities and challenges for the chemical industry to apply 21st-century toxicity testing.Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendiumSuccessful drug development despite adverse preclinical findings part 2: examples.Successful drug development despite adverse preclinical findings part 1: processes to address issues and most important findingsBiological Basis of Differential Susceptibility to Hepatocarcinogenesis among Mouse StrainsSmall-molecule modulators of the constitutive androstane receptor.Induction of endogenous retroelements as a potential mechanism for mouse-specific drug-induced carcinogenicity.PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver.Mode-of-action analysis for induction of rat liver tumors by pyrethrins: relevance to human cancer risk.Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation.The roles of the toxicologic pathologist in cancer research.Guidance for the classification of carcinogens under the Globally Harmonised System of Classification and Labelling of Chemicals (GHS).Hepatic enzyme induction: histopathology.Historical perspective on the use of animal bioassays to predict carcinogenicity: evolution in design and recognition of utility.The toxicity and pathology of selected dietary herbal medicines.Dose-response approaches for nuclear receptor-mediated modes of action for liver carcinogenicity: Results of a workshop.Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study.Mode of action and dose-response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study.Human relevance framework for rodent liver tumors induced by the insecticide sulfoxaflor.Mode of action analysis for pesticide-induced rodent liver tumours involving activation of the constitutive androstane receptor: relevance to human cancer risk.Risk assessments for chronic exposure of children and prospective parents to ethylbenzene (CAS No. 100-41-4).A Balanced Risk-Benefit Analysis to Determine Human Risks Associated with Pyrrolizidine Alkaloids (PA)-The Case of Tea and Herbal Infusions.
P2860
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P2860
Mode of action in relevance of rodent liver tumors to human cancer risk.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Mode of action in relevance of rodent liver tumors to human cancer risk.
@en
Mode of action in relevance of rodent liver tumors to human cancer risk.
@nl
type
label
Mode of action in relevance of rodent liver tumors to human cancer risk.
@en
Mode of action in relevance of rodent liver tumors to human cancer risk.
@nl
prefLabel
Mode of action in relevance of rodent liver tumors to human cancer risk.
@en
Mode of action in relevance of rodent liver tumors to human cancer risk.
@nl
P2093
P2860
P356
P1476
Mode of action in relevance of rodent liver tumors to human cancer risk.
@en
P2093
Henri C Pitot
James E Klaunig
Michael P Holsapple
Samuel M Cohen
Timothy Pastoor
Vicki L Dellarco
Yvonne P Dragan
P2860
P356
10.1093/TOXSCI/KFJ001
P577
2005-10-12T00:00:00Z