about
Cellular Senescence as the Causal Nexus of AgingmiR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18Big mice die young but large animals live longerElimination of proliferating cells unmasks the shift from senescence to quiescence caused by rapamycinWhy men age faster but reproduce longer than women: mTOR and evolutionary perspectivesDNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescenceContact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence programHyper-mitogenic drive coexists with mitotic incompetence in senescent cells.DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cellsVitiligo: a possible model of degenerative diseases.The LIM-only protein FHL2 mediates ras-induced transformation through cyclin D1 and p53 pathways.From rapalogs to anti-aging formula.Aging, cellular senescence, and cancerStrategic cell-cycle regulatory features that provide mammalian cells with tunable G1 length and reversible G1 arrest.Gerosuppression in confluent cells.Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion.Hormesis does not make sense except in the light of TOR-driven aging.NCI's provocative questions on cancer: some answers to ignite discussion.Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging.Geroconversion: irreversible step to cellular senescenceRejuvenating immunity: "anti-aging drug today" eight years later.Antitumour potential of BPT: a dual inhibitor of cdk4 and tubulin polymerizationDeficiency of the cyclin kinase inhibitor p21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunity.Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).Answering the ultimate question "what is the proximal cause of aging?"Recent discoveries in the cycling, growing and aging of the p53 fieldSuppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2.AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD(+) elevation.Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes.Microtubule binding and disruption and induction of premature senescence by disorazole C(1).M(o)TOR of aging: MTOR as a universal molecular hypothalamusRapamycin extends life- and health span because it slows aging.Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease.Aging is not programmed: genetic pseudo-program is a shadow of developmental growth.Uncoupling reproduction from metabolism extends chronological lifespan in yeast.Cell cycle arrest is not senescence.Cellular Senescence - its role in cancer and the response to ionizing radiation.Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis.Thioredoxin overexpression in HT-1080 cells induced cellular senescence and sensitization to gamma radiation.Progeria, rapamycin and normal aging: recent breakthrough.
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Cell senescence and hypermitogenic arrest.
@ast
Cell senescence and hypermitogenic arrest.
@en
type
label
Cell senescence and hypermitogenic arrest.
@ast
Cell senescence and hypermitogenic arrest.
@en
prefLabel
Cell senescence and hypermitogenic arrest.
@ast
Cell senescence and hypermitogenic arrest.
@en
P2860
P1433
P1476
Cell senescence and hypermitogenic arrest.
@en
P2860
P304
P356
10.1038/SJ.EMBOR.EMBOR806
P577
2003-04-01T00:00:00Z