Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity
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Animal models for the study of HCVXenotransplantation models to study the effects of toxicants on human fetal tissuesUsage of adenovirus expressing thymidine kinase mediated hepatocellular damage for enabling mouse liver repopulation with allogenic or xenogenic hepatocytesAdvances in Engineered Liver Models for Investigating Drug-Induced Liver InjuryGeneration of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID MicePrinciples of liver regeneration and growth homeostasis.Mice with chimeric livers are an improved model for human lipoprotein metabolismThe history and use of human hepatocytes for the treatment of liver diseases: the first 100 patients.Determinants of hepatitis B and delta virus host tropism.The nude mouse as model for liver deficiency study and treatment and xenotransplantation.The Use of Induced Pluripotent Stem Cells for the Study and Treatment of Liver Diseases.In vivo models of hepatitis B and C virus infection.Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice.Three-dimensional bio-printing: A new frontier in oncology research.Mouse chimeras as a system to investigate development, cell and tissue function, disease mechanisms and organ regeneration.Chimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies.Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver.Novel pre-clinical methodologies for pharmacokinetic drug-drug interaction studies: spotlight on "humanized" animal models.The application of engineered liver tissues for novel drug discovery.Assessing the therapeutic potential of lab-made hepatocytes.In Vitro Generated Hepatocyte-Like Cells: A Novel Tool in Regenerative Medicine and Drug Discovery.Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiologic Spaces, and Hepatic Enzymes and Transporters.Human hepatic stem cells transplanted into a fulminant hepatic failure Alb-TRECK/SCID mouse model exhibit liver reconstitution and drug metabolism capabilities.Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism.Successful Engraftment of Human Hepatocytes in uPA-SCID and FRG(®) KO Mice.A potent human neutralizing antibody Fc-dependently reduces established HBV infectionsMolecular detection and quantification of Plasmodium falciparum-infected human hepatocytes in chimeric immune-deficient mice.Microphysical space of a liver sinusoid device enables simplified long-term maintenance of chimeric mouse-expanded human hepatocytes.Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers.Troglitazone metabolism and transporter effects in chimeric mice: a comparison between chimeric humanized and chimeric murinized FRG mice.Lumiracoxib metabolism in male C57bl/6J mice: characterisation of novel in vivo metabolites.Endogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone.Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers.Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models.Diclofenac metabolism in the mouse: novel in vivo metabolites identified by high performance liquid chromatography coupled to linear ion trap mass spectrometry.The metabolic fate of fenclozic acid in chimeric mice with a humanized liverIn vitro and in vivo metabolisms of 1-pentyl-3-(4-methyl-1-naphthoyl)indole (JWH-122)
P2860
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P2860
Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Chimeric mice with humanized l ...... olism, excretion, and toxicity
@ast
Chimeric mice with humanized l ...... olism, excretion, and toxicity
@en
type
label
Chimeric mice with humanized l ...... olism, excretion, and toxicity
@ast
Chimeric mice with humanized l ...... olism, excretion, and toxicity
@en
prefLabel
Chimeric mice with humanized l ...... olism, excretion, and toxicity
@ast
Chimeric mice with humanized l ...... olism, excretion, and toxicity
@en
P2860
P1476
Chimeric mice with humanized l ...... olism, excretion, and toxicity
@en
P2093
Julio Davila
P2860
P304
P356
10.1007/978-1-60761-688-7_27
P407
P577
2010-01-01T00:00:00Z