Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors).
about
Molecular and functional properties of P2X receptors--recent progress and persisting challengesInsights into the channel gating of P2X receptors from structures, dynamics and small moleculesSize matters in activation/inhibition of ligand-gated ion channelsPrinciples and properties of ion flow in P2X receptorsInsights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide PolymorphismsMolecular mechanism of ATP binding and ion channel activation in P2X receptorsX-ray structures define human P2X3 receptor gating cycle and antagonist actionConductance of P2X4 purinergic receptor is determined by conformational equilibrium in the transmembrane regionImaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorinP2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology.Neuromodulation by extracellular ATP and P2X receptors in the CNS.Identification of functionally important residues of the rat P2X4 receptor by alanine scanning mutagenesis of the dorsal fin and left flipper domains.Multiple roles of the extracellular vestibule amino acid residues in the function of the rat P2X4 receptor.Functional identification of close proximity amino acid side chains within the transmembrane-spanning helixes of the P2X2 receptorQuantifying Ca2+ current and permeability in ATP-gated P2X7 receptors.Full-open and closed CFTR channels, with lateral tunnels from the cytoplasm and an alternative position of the F508 region, as revealed by molecular dynamics.Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic painRole of domain calcium in purinergic P2X2 receptor channel desensitizationRoles of the lateral fenestration residues of the P2X₄ receptor that contribute to the channel function and the deactivation effect of ivermectinAllosteric modulation of Ca2+ flux in ligand-gated cation channel (P2X4) by actions on lateral portalsGating mechanism of a P2X4 receptor developed from normal mode analysis and molecular dynamics simulationsAgonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel.High potency zinc modulation of human P2X2 receptors and low potency zinc modulation of rat P2X2 receptors share a common molecular mechanismMolecular modelling and molecular dynamics of CFTR.Inter- and intrasubunit interactions between transmembrane helices in the open state of P2X receptor channels.Structural and functional properties of the rat P2X4 purinoreceptor extracellular vestibule during gating.Insight into DEG/ENaC channel gating from genetics and structure.P2X receptors as drug targets.Unanticipated parallels in architecture and mechanism between ATP-gated P2X receptors and acid sensing ion channels.Heteromeric assembly of P2X subunits.Key sites for P2X receptor function and multimerization: overview of mutagenesis studies on a structural basis.Ectodomain movements of an ATP-gated ion channel (P2X2 receptor) probed by disulfide locking.Functional Architecture of the Cytoplasmic Entrance to the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore.Role of the juxtamembrane region of cytoplasmic loop 3 in the gating and conductance of the cystic fibrosis transmembrane conductance regulator chloride channel.P2X Receptor Activation.A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis.Direct gating of ATP-activated ion channels (P2X2 receptors) by lipophilic attachment at the outer end of the second transmembrane domainP2X4 Receptor in Silico and Electrophysiological Approaches Reveal Insights of Ivermectin and Zinc Allosteric Modulation.Intersubunit physical couplings fostered by the left flipper domain facilitate channel opening of P2X4 receptors.
P2860
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P2860
Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors).
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Preferential use of unobstruct ...... ion channels (P2X receptors).
@ast
Preferential use of unobstruct ...... ion channels (P2X receptors).
@en
type
label
Preferential use of unobstruct ...... ion channels (P2X receptors).
@ast
Preferential use of unobstruct ...... ion channels (P2X receptors).
@en
prefLabel
Preferential use of unobstruct ...... ion channels (P2X receptors).
@ast
Preferential use of unobstruct ...... ion channels (P2X receptors).
@en
P2093
P2860
P356
P1476
Preferential use of unobstruct ...... d ion channels (P2X receptors)
@en
P2093
Baljit S Khakh
Damien S K Samways
Terrance M Egan
P2860
P304
13800-13805
P356
10.1073/PNAS.1017550108
P407
P577
2011-08-01T00:00:00Z