Deep mutational scanning: assessing protein function on a massive scale.
about
Weak selection and protein evolutionActivity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesisRational Protein Engineering Guided by Deep Mutational ScanningOptimization of affinity, specificity and function of designed influenza inhibitors using deep sequencingApplications of comparative evolution to human disease geneticsVersatile communication strategies among tandem WW domain repeatsExperimental evolution of protein-protein interaction networksHigh-throughput profiling of point mutations across the HIV-1 genome.Detection and sequence/structure mapping of biophysical constraints to protein variation in saturated mutational libraries and protein sequence alignments with a dedicated serverIn silico Mapping of Protein Unfolding Mutations for Inherited DiseaseInferring fitness landscapes by regression produces biased estimates of epistasis.An experimentally determined evolutionary model dramatically improves phylogenetic fit.The inherent mutational tolerance and antigenic evolvability of influenza hemagglutinin.Enrich: software for analysis of protein function by enrichment and depletion of variants.High-throughput mutagenesis reveals functional determinants for DNA targeting by activation-induced deaminase.Improved modeling of side-chain--base interactions and plasticity in protein--DNA interface designAn experimentally informed evolutionary model improves phylogenetic fit to divergent lactamase homologsLarge-scale de novo DNA synthesis: technologies and applications.High-efficiency genome editing and allele replacement in prototrophic and wild strains of SaccharomycesPFunkel: efficient, expansive, user-defined mutagenesis.Massively parallel determination and modeling of endonuclease substrate specificityDeep mutational scanning of an antibody against epidermal growth factor receptor using mammalian cell display and massively parallel pyrosequencing.Measuring the activity of protein variants on a large scale using deep mutational scanning.SORTCERY-A High-Throughput Method to Affinity Rank Peptide Ligands.Deep mutational scanning: a new style of protein scienceCombining natural sequence variation with high throughput mutational data to reveal protein interaction sites.How structural and physicochemical determinants shape sequence constraints in a functional enzymeHigh-resolution sequence-function mapping of full-length proteins.Rapid construction of metabolite biosensors using domain-insertion profiling.Deep Mutational Scans as a Guide to Engineering High Affinity T Cell Receptor Interactions with Peptide-bound Major Histocompatibility Complex.Mapping Proteome-Wide Targets of Environmental Chemicals Using Reactivity-Based Chemoproteomic PlatformsEvidence for Amino Acid Snorkeling from a High-Resolution, In Vivo Analysis of Fis1 Tail-Anchor Insertion at the Mitochondrial Outer MembraneA Gradient of Sitewise Diversity Promotes Evolutionary Fitness for Binder Discovery in a Three-Helix Bundle Protein Scaffold.A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function.Triallelic Population Genomics for Inferring Correlated Fitness Effects of Same Site Nonsynonymous Mutations.A novel test for selection on cis-regulatory elements reveals positive and negative selection acting on mammalian transcriptional enhancers.High-throughput analysis of in vivo protein stability.Deep mutational scanning of an RRM domain of the Saccharomyces cerevisiae poly(A)-binding protein.Contemporary, yeast-based approaches to understanding human genetic variation.The power of fission: yeast as a tool for understanding complex splicing.
P2860
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P2860
Deep mutational scanning: assessing protein function on a massive scale.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Deep mutational scanning: assessing protein function on a massive scale.
@ast
Deep mutational scanning: assessing protein function on a massive scale.
@en
type
label
Deep mutational scanning: assessing protein function on a massive scale.
@ast
Deep mutational scanning: assessing protein function on a massive scale.
@en
prefLabel
Deep mutational scanning: assessing protein function on a massive scale.
@ast
Deep mutational scanning: assessing protein function on a massive scale.
@en
P2860
P1476
Deep mutational scanning: assessing protein function on a massive scale.
@en
P2093
Carlos L Araya
Douglas M Fowler
P2860
P304
P356
10.1016/J.TIBTECH.2011.04.003
P577
2011-05-10T00:00:00Z