The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families - Wikidata - awgldk - TriplyDB

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

http://www.wikidata.org/entity/Q35211894

about

SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex TIP120A associates with cullins and modulates ubiquitin ligase activity Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II Principles of interleukin (IL)-6-type cytokine signalling and its regulation Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation Structural and functional insights into the B30.2/SPRY domain.Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells Functional analysis of Asb-1 using genetic modification in mice Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3 BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2 Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34 Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex The HIV-1 Vif PPLP motif is necessary for human APOBEC3G binding and degradation The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activities Signaling by STATs Negative regulation of cytokine signaling and immune responses by SOCS proteins Systematic discovery of new recognition peptides mediating protein interaction networks WSB1: from homeostasis to hypoxia Suppressors of Cytokine Signaling in Sickness and in Health of Pancreatic β-Cells The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions Atlas on substrate recognition subunits of CRL2 E3 ligases LIF-STAT signaling and trophoblast biology Ubiquitination-mediated regulation of interferon responses Suppression of APOBEC3-mediated restriction of HIV-1 by Vif

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The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

http://www.wikidata.org/entity/Q35211894

description

1998 nî lūn-bûn

@nan

1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

1998年の論文

@ja

1998年論文

@yue

1998年論文

@zh-hant

1998年論文

@zh-hk

1998年論文

@zh-mo

1998年論文

@zh-tw

1998年论文

@wuu

name

The Elongin BC complex interac ...... t, and ankyrin repeat families

@ast

The Elongin BC complex interac ...... t, and ankyrin repeat families

@en

type

label

The Elongin BC complex interac ...... t, and ankyrin repeat families

@ast

The Elongin BC complex interac ...... t, and ankyrin repeat families

@en

prefLabel

The Elongin BC complex interac ...... t, and ankyrin repeat families

@ast

The Elongin BC complex interac ...... t, and ankyrin repeat families

@en

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P1433

Genes & Development

P1476

The Elongin BC complex interac ...... t, and ankyrin repeat families

@en

P2093

D Haque

http://www.w3.org/2001/XMLSchema#string

J W Conaway

http://www.w3.org/2001/XMLSchema#string

L Liu

http://www.w3.org/2001/XMLSchema#string

R C Conaway

http://www.w3.org/2001/XMLSchema#string

S Sato

http://www.w3.org/2001/XMLSchema#string

T Kamura

http://www.w3.org/2001/XMLSchema#string

P2860

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

A family of cytokine-inducible inhibitors of signalling

A new protein containing an SH2 domain that inhibits JAK kinases

Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations

Twenty proteins containing a C-terminal SOCS box form five structural classes

Cloning and characterization of novel CIS family genes

Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3

Inhibition of transcription elongation by the VHL tumor suppressor protein

Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II

Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C

P304

3872-3881

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1101/GAD.12.24.3872

http://www.w3.org/2001/XMLSchema#string

P433

24

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P478

12

http://www.w3.org/2001/XMLSchema#string

P50

William G. Kaelin

P577

1998-12-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

13417834

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P698

9869640

http://www.w3.org/2001/XMLSchema#string

P932

317264

http://www.w3.org/2001/XMLSchema#string