Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus. - Wikidata - awgldk - TriplyDB

Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus.

Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus.

http://www.wikidata.org/entity/Q35542816

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Use of RNA sequencing to evaluate rheumatic disease patients Interferon-regulatory factors determine macrophage phenotype polarization Sexual dimorphism in autoimmunity Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2.Gender-dependent expression of murine Irf5 gene: implications for sex bias in autoimmunity Interferon regulatory factor 5-dependent immune responses in the draining lymph node protect against West Nile virus infection.RNA-Seq for enrichment and analysis of IRF5 transcript expression in SLE.The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share Interferon regulatory factors in human lupus pathogenesis Genetic polymorphism of interferon regulatory factor 5 (IRF5) correlates with allograft acute rejection of liver transplantation.Novel approach to bile duct damage in primary biliary cirrhosis: participation of cellular senescence and autophagy.TRIpartite motif 21 (TRIM21) differentially regulates the stability of interferon regulatory factor 5 (IRF5) isoforms.The type I interferon system in the etiopathogenesis of autoimmune diseases.Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression.Much More than M1 and M2 Macrophages, There are also CD169(+) and TCR(+) Macrophages.Interferon regulatory factor 5 activation in monocytes of systemic lupus erythematosus patients is triggered by circulating autoantigens independent of type I interferons Genetics of serum concentration of IL-6 and TNFα in systemic lupus erythematosus and rheumatoid arthritis: a candidate gene analysis.Mangiferin inhibits macrophage classical activation via downregulating interferon regulatory factor 5 expression.The genetics of lupus: a functional perspective.Monocytes from Irf5-/- mice have an intrinsic defect in their response to pristane-induced lupus.Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women.The type I interferons: Basic concepts and clinical relevance in immune-mediated inflammatory diseases.Genetics of SLE: functional relevance for monocytes/macrophages in disease Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus RETRACTED: The COP9 signalosome interacts with and regulates interferon regulatory factor 5 protein stability.The interferon-alpha signature of systemic lupus erythematosus.Irf5-deficient mice are protected from pristane-induced lupus via increased Th2 cytokines and altered IgG class switching.Specific detection of interferon regulatory factor 5 (IRF5): A case of antibody inequality.Interferon regulatory factor 5 in the pathogenesis of systemic lupus erythematosus.Identification of three new cis-regulatory IRF5 polymorphisms: in vitro studies.DNA-reactive B cells in lupus.Cis-regulation of IRF5 expression is unable to fully account for systemic lupus erythematosus association: analysis of multiple experiments with lymphoblastoid cell lines.IRF5 is elevated in childhood-onset SLE and regulated by histone acetyltransferase and histone deacetylase inhibitors.Four Promoters of IRF5 Respond Distinctly to Stimuli and are Affected by Autoimmune-Risk Polymorphisms B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation.Corrected and Republished from: The COP9 Signalosome Interacts with and Regulates Interferon Regulatory Factor 5 Protein Stability.Genetics of human lupus nephritis.Lineage-Specific Functionality of an Interferon Regulatory Factor 5 Lupus Risk Haplotype: Lack of B Cell Intrinsic Effects.Plasma Cell Differentiation Pathways in Systemic Lupus Erythematosus.

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Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus.

http://www.wikidata.org/entity/Q35542816

description

2010 nî lūn-bûn

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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Genetic variants and disease-a ...... systemic lupus erythematosus.

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Genetic variants and disease-a ...... systemic lupus erythematosus.

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type

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Genetic variants and disease-a ...... systemic lupus erythematosus.

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Genetic variants and disease-a ...... systemic lupus erythematosus.

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Genetic variants and disease-a ...... systemic lupus erythematosus.

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Genetic variants and disease-a ...... systemic lupus erythematosus.

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Arthritis & Rheumatology

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Genetic variants and disease-a ...... systemic lupus erythematosus.

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P2093

Betsy J Barnes

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Chuan Wang

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Di Feng

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Gunnar Alm

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Gunnel Nordmark

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Lars Rönnblom

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Maija-Leena Eloranta

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Niquiche Sangster-Guity

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Rivka C Stone

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P2860

Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus

Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes

Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus

Interferon regulatory factor 5, a novel mediator of cell cycle arrest and cell death

Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function

Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

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562-573

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10.1002/ART.27223

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2

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62

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Ann-Christine Syvänen

Snaevar Sigurdsson

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2010-02-01T00:00:00Z

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41175641

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20112383

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3213692

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