Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept.
about
Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cellActivation of mitogen-activating protein kinase by glucose is not required for insulin secretioncAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37)Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells.Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cellscAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cellsOver-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic beta-cell lines for use in transplantationGenetically engineered pancreatic beta-cell lines for cell therapy of diabetes.PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.Ascorbic acid is essential for the release of insulin from scorbutic guinea pig pancreatic islets.Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.Review article: control of gall-bladder motor function.Glucagon-like peptide-1 synthetic analogs: new therapeutic agents for use in the treatment of diabetes mellitus.New insights concerning the glucose-dependent insulin secretagogue action of glucagon-like peptide-1 in pancreatic beta-cells.Black widow spider alpha-latrotoxin: a presynaptic neurotoxin that shares structural homology with the glucagon-like peptide-1 family of insulin secretagogic hormones.Palmitic acid acutely inhibits acetylcholine- but not GLP-1-stimulated insulin secretion in mouse pancreatic islets.Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element.Targeting beta-cell cyclic 3'5' adenosine monophosphate for the development of novel drugs for treating type 2 diabetes mellitus. A review.Protein kinase A takes center stage in ATP-dependent insulin secretionAttenuation of insulin secretion by insulin-like growth factor 1 is mediated through activation of phosphodiesterase 3B.Diabetes mellitus, part 1: physiology and complications.Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 releaseLeptin inhibits insulin secretion by activation of phosphodiesterase 3B.Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells.New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout miceCharacterization of a novel calcium response element in the glucagon gene.Gene-specific transcriptional activity of the insulin cAMP-responsive element is conferred by NF-Y in combination with cAMP response element-binding protein.Characterization of a novel protein kinase C response element in the glucagon gene.Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM.Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM.Amplification of exocytosis by Ca2+-induced Ca2+ release in INS-1 pancreatic beta cells.Exendin-4 as a stimulator of rat insulin I gene promoter activity via bZIP/CRE interactions sensitive to serine/threonine protein kinase inhibitor Ro 31-8220.Application of patch clamp methods to the study of calcium currents and calcium channelsCalcium: its modulation in liver by cross-talk between the actions of glucagon and calcium-mobilizing agonists.The calcium/calmodulin-dependent phosphodiesterase PDE1C down-regulates glucose-induced insulin secretion.Mode of regulation of the extracellular signal-regulated kinases in the pancreatic beta-cell line MIN6 and their implication in the regulation of insulin gene transcription.Rapid activation and nuclear translocation of mitogen-activated protein kinases in response to physiological concentration of glucose in the MIN6 pancreatic beta cell line.Differential expression of the protein kinase A regulatory subunit (RIalpha) in pancreatic endocrine cells.
P2860
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P2860
Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Signal transduction crosstalk ...... he glucose competence concept.
@ast
Signal transduction crosstalk ...... he glucose competence concept.
@en
type
label
Signal transduction crosstalk ...... he glucose competence concept.
@ast
Signal transduction crosstalk ...... he glucose competence concept.
@en
prefLabel
Signal transduction crosstalk ...... he glucose competence concept.
@ast
Signal transduction crosstalk ...... he glucose competence concept.
@en
P2860
P1476
Signal transduction crosstalk ...... he glucose competence concept.
@en
P2093
P2860
P304
P356
10.1016/0968-0004(92)90006-U
P577
1992-10-01T00:00:00Z