Discrimination of muscle and neuronal Na-channel subtypes by binding competition between [3H]saxitoxin and mu-conotoxins.
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Cooccupancy of the outer vestibule of voltage-gated sodium channels by micro-conotoxin KIIIA and saxitoxin or tetrodotoxinUsing the deadly mu-conotoxins as probes of voltage-gated sodium channelsConotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel InhibitionStructure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activityStructural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIAUltra-slow inactivation in mu1 Na+ channels is produced by a structural rearrangement of the outer vestibuleTwo toxins from Conus striatus that individually induce tetanic paralysis.Pore residues critical for mu-CTX binding to rat skeletal muscle Na+ channels revealed by cysteine mutagenesis.μ-conotoxin KIIIA derivatives with divergent affinities versus efficacies in blocking voltage-gated sodium channels.A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule.Competitive binding interaction between Zn2+ and saxitoxin in cardiac Na+ channels. Evidence for a sulfhydryl group in the Zn2+/saxitoxin binding site.Trimethyloxonium modification of batrachotoxin-activated Na channels alters functionally important protein residuesExtrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel (rSkM1) contribute to the mu-conotoxin GIIIA binding site.Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule.Novel interactions identified between micro -Conotoxin and the Na+ channel domain I P-loop: implications for toxin-pore binding geometry.Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA.Modulation of sodium-channel mRNA levels in rat skeletal muscleThe M-superfamily of conotoxins: a review.μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerveEvidence for paralytic shellfish poisons in the freshwater cyanobacterium Lyngbya wollei (Farlow ex Gomont) comb. nov.Docking of mu-conotoxin GIIIA in the sodium channel outer vestibule.Use of geographutoxin II (mu-conotoxin) for the study of neuromuscular transmission in mouse.Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor.Use-dependent block of the voltage-gated Na(+) channel by tetrodotoxin and saxitoxin: effect of pore mutations that change ionic selectivity.Block of voltage-dependent sodium currents by the substance P receptor antagonist (+/-)-CP-96,345 in neurones cultured from rat cortex.Contribution of sialic acid to the voltage dependence of sodium channel gating. A possible electrostatic mechanism.Molecular surface of tarantula toxins interacting with voltage sensors in K(v) channelsmu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains.Electrostatic and steric contributions to block of the skeletal muscle sodium channel by mu-conotoxin.Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7.The outer vestibule of the Na+ channel-toxin receptor and modulator of permeation as well as gating.The tetrodotoxin receptor of voltage-gated sodium channels--perspectives from interactions with micro-conotoxins.Residue Gly1326 of the N-type calcium channel alpha 1B subunit controls reversibility of omega-conotoxin GVIA and MVIIA block.Clockwise domain arrangement of the sodium channel revealed by (mu)-conotoxin (GIIIA) docking orientation.Functional and structural features of gamma-zeathionins, a new class of sodium channel blockers.Conotoxins as sensors of local pH and electrostatic potential in the outer vestibule of the sodium channel.Pacific ciguatoxin-1b effect over Na+ and K+ currents, inositol 1,4,5-triphosphate content and intracellular Ca2+ signals in cultured rat myotubes.Modification of Arg-13 of mu-conotoxin GIIIA with piperidinyl-Arg analogs and their relation to the inhibition of sodium channels.Charge conversion enables quantification of the proximity between a normally-neutral mu-conotoxin (GIIIA) site and the Na+ channel pore.Molecular basis of isoform-specific micro-conotoxin block of cardiac, skeletal muscle, and brain Na+ channels.
P2860
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P2860
Discrimination of muscle and neuronal Na-channel subtypes by binding competition between [3H]saxitoxin and mu-conotoxins.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Discrimination of muscle and n ...... H]saxitoxin and mu-conotoxins.
@ast
Discrimination of muscle and n ...... H]saxitoxin and mu-conotoxins.
@en
type
label
Discrimination of muscle and n ...... H]saxitoxin and mu-conotoxins.
@ast
Discrimination of muscle and n ...... H]saxitoxin and mu-conotoxins.
@en
prefLabel
Discrimination of muscle and n ...... H]saxitoxin and mu-conotoxins.
@ast
Discrimination of muscle and n ...... H]saxitoxin and mu-conotoxins.
@en
P2093
P2860
P356
P1476
Discrimination of muscle and n ...... H]saxitoxin and mu-conotoxins.
@en
P2093
B M Olivera
E Moczydlowski
G R Strichartz
P2860
P304
P356
10.1073/PNAS.83.14.5321
P407
P577
1986-07-01T00:00:00Z