Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instability
about
Advances in mechanisms of genetic instability related to hereditary neurological diseases.Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiaeRole of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesisStoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic miceDiverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells.Convergent transcription through a long CAG tract destabilizes repeats and induces apoptosisTopoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cells.Potassium bromate, a potent DNA oxidizing agent, exacerbates germline repeat expansion in a fragile X premutation mouse modelKinetics of endogenous mouse FEN1 in base excision repair.Defining genetic factors that modulate intergenerational CAG repeat instability in Drosophila melanogasterA 5', 8-cyclo-2'-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase βMicrosatellite repeat instability and neurological disease.Repeat instability during DNA repair: Insights from model systemsInstability of (CTG)n•(CAG)n trinucleotide repeats and DNA synthesisHaploinsufficiency of yeast FEN1 causes instability of expanded CAG/CTG tracts in a length-dependent manner.DNA base excision repair: a mechanism of trinucleotide repeat expansion.The Repeat Expansion Diseases: The dark side of DNA repair.Repeat instability: mechanisms of dynamic mutations.The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founder.Trinucleotide repeat deletion via a unique hairpin bypass by DNA polymerase β and alternate flap cleavage by flap endonuclease 1.Mitochondrial DNA damage and repair in neurodegenerative disorders.Evidence for base excision repair processing of DNA interstrand crosslinks.Features of trinucleotide repeat instability in vivo.ATM and ATR protect the genome against two different types of tandem repeat instability in Fragile X premutation mice.Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stabilityCoordination between polymerase beta and FEN1 can modulate CAG repeat expansion.Abnormal base excision repair at trinucleotide repeats associated with diseases: a tissue-selective mechanism.Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion.Dna2 on the road to Okazaki fragment processing and genome stability in eukaryotes.The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once.DNA Repair Endonucleases: Physiological Roles and Potential as Drug Targets.Saccharomyces cerevisiae Srs2 DNA helicase selectively blocks expansions of trinucleotide repeats.Replication-dependent instability at (CTG) x (CAG) repeat hairpins in human cells.Fen1 does not control somatic hypermutability of the (CTG)(n)*(CAG)(n) repeat in a knock-in mouse model for DM1.Srs2 helicase of Saccharomyces cerevisiae selectively unwinds triplet repeat DNA.
P2860
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P2860
Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instability
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Nuclease-deficient FEN-1 block ...... inucleotide repeat instability
@ast
Nuclease-deficient FEN-1 block ...... inucleotide repeat instability
@en
type
label
Nuclease-deficient FEN-1 block ...... inucleotide repeat instability
@ast
Nuclease-deficient FEN-1 block ...... inucleotide repeat instability
@en
prefLabel
Nuclease-deficient FEN-1 block ...... inucleotide repeat instability
@ast
Nuclease-deficient FEN-1 block ...... inucleotide repeat instability
@en
P2860
P1476
Nuclease-deficient FEN-1 block ...... inucleotide repeat instability
@en
P2093
Craig Spiro
Cynthia T McMurray
P2860
P304
P356
10.1128/MCB.23.17.6063-6074.2003
P407
P577
2003-09-01T00:00:00Z