Activation of caspase-6 in aging and mild cognitive impairment - Wikidata - awgldk - TriplyDB

Activation of caspase-6 in aging and mild cognitive impairment

Activation of caspase-6 in aging and mild cognitive impairment

http://www.wikidata.org/entity/Q35691585

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Caspases in synaptic plasticity APP binds DR6 to trigger axon pruning and neuron death via distinct caspases Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation Mitochondrial abnormalities in Alzheimer's disease: possible targets for therapeutic intervention The crystal structure of caspase-6, a selective effector of axonal degeneration Zinc-mediated Allosteric Inhibition of Caspase-6 Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6 Inhibitory Mechanism of Caspase-6 Phosphorylation Revealed by Crystal Structures, Molecular Dynamics Simulations, and Biochemical Assays Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization On the central role of brain connectivity in neurodegenerative disease progression A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C Spatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampus.A quantitative method for the specific assessment of caspase-6 activity in cell culture Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.Nitrous oxide plus isoflurane induces apoptosis and increases beta-amyloid protein levels Analysis of Alzheimer's disease severity across brain regions by topological analysis of gene co-expression networks.Effects of transplanted GDNF gene modified marrow stromal cells on focal cerebral ischemia in rats.Alternatively spliced caspase-6B isoform inhibits the activation of caspase-6A.Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimer's disease as based on APOE genotype.Anti-amyloidogenic and anti-apoptotic role of melatonin in Alzheimer disease Proteolysis of calcineurin is increased in human hippocampus during mild cognitive impairment and is stimulated by oligomeric Abeta in primary cell culture.Familial amyloid precursor protein mutants cause caspase-6-dependent but amyloid β-peptide-independent neuronal degeneration in primary human neuron cultures.Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations.Expression and activation of caspase-6 in human fetal and adult tissues The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics Identification of Caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation.Disturbed neurotransmitter transporter expression in Alzheimer's disease brain Transcriptomic analysis unveils correlations between regulative apoptotic caspases and genes of cholesterol homeostasis in human brain.Characterization of Aldh2 (-/-) mice as an age-related model of cognitive impairment and Alzheimer's disease Overview and findings from the religious orders study Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.Loss of phospholipid asymmetry and elevated brain apoptotic protein levels in subjects with amnestic mild cognitive impairment and Alzheimer disease.Aging is associated with altered inflammatory, arachidonic acid cascade, and synaptic markers, influenced by epigenetic modifications, in the human frontal cortex.Targets of caspase-6 activity in human neurons and Alzheimer disease.Developmental patterns of DR6 in normal human hippocampus and in Down syndrome Biomarkers for early diagnosis of Alzheimer disease: 'ALZheimer ASsociated gene'--a new blood biomarker?Caspase-6 activity predicts lower episodic memory ability in aged individuals Cerebrospinal fluid tau cleaved by caspase-6 reflects brain levels and cognition in aging and Alzheimer disease

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Activation of caspase-6 in aging and mild cognitive impairment

http://www.wikidata.org/entity/Q35691585

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Activation of caspase-6 in aging and mild cognitive impairment

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Activation of caspase-6 in aging and mild cognitive impairment

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type

label

Activation of caspase-6 in aging and mild cognitive impairment

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Activation of caspase-6 in aging and mild cognitive impairment

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prefLabel

Activation of caspase-6 in aging and mild cognitive impairment

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Activation of caspase-6 in aging and mild cognitive impairment

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The American Journal of Pathology

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Activation of caspase-6 in aging and mild cognitive impairment

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Andréa C LeBlanc

http://www.w3.org/2001/XMLSchema#string

David Bennett

http://www.w3.org/2001/XMLSchema#string

Elliott J Mufson

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Martine Bourdeau

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Meena Bhattacharjee

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Steffen Albrecht

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P2860

Neuropathological stageing of Alzheimer-related changes

Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).

Mild cognitive impairment represents early-stage Alzheimer disease.

Natural history of mild cognitive impairment in older persons.

Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry.

Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.

Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease

A focus on the synapse for neuroprotection in Alzheimer disease and other dementias.

Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation.

Making the diagnosis of Alzheimer's disease. A primer for practicing pathologists.

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