Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway - Wikidata - awgldk - TriplyDB

Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway

Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway

http://www.wikidata.org/entity/Q35719884

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Protein characterization of a candidate mechanism SNP for Crohn's disease: the macrophage stimulating protein R689C substitution Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice Structure of an Fab–Protease Complex Reveals a Highly Specific Non-canonical Mechanism of Inhibition Peptide Length and Leaving-Group Sterics Influence Potency of Peptide Phosphonate Protease Inhibitors Crystal Structure of the Sema-PSI Extracellular Domain of Human RON Receptor Tyrosine Kinase A Reverse Binding Motif That Contributes to Specific Protease Inhibition by Antibodies Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis Laminin-332 cleavage by matriptase alters motility parameters of prostate cancer cells.Positional scanning synthetic combinatorial libraries for substrate profiling.A sequence and structure based method to predict putative substrates, functions and regulatory networks of endo proteases.PRSS3 is a prognostic marker in invasive ductal carcinoma of the breast.Local protease signaling contributes to neural tube closure in the mouse embryo Tumor detection by imaging proteolytic activity Matriptase zymogen supports epithelial development, homeostasis and regeneration Ron-receptor tyrosine kinase in tumorigenesis and metastasis Met-related receptor tyrosine kinase Ron in tumor growth and metastasis.Role of STK in mouse liver macrophage and endothelial cell responsiveness during acute endotoxemia.Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCdelta.Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109 Phosphorylation of the SRC epithelial substrate Trask is tightly regulated in normal epithelia but widespread in many human epithelial cancers.Endogenous expression of matriptase in neural progenitor cells promotes cell migration and neuron differentiation.Matriptase and MET are prominently expressed at the site of bone metastasis in renal cell carcinoma: immunohistochemical analysis.Matriptase is inhibited by extravascular antithrombin in epithelial cells but not in most carcinoma cells Matriptase promotes inflammatory cell accumulation and progression of established epidermal tumors.The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis Mechanisms for the control of matriptase activity in the absence of sufficient HAI-1 Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells Selective Inhibition of Prostasin in Human Enterocytes by the Integral Membrane Kunitz-Type Serine Protease Inhibitor HAI-2 Myeloid-specific expression of Ron receptor kinase promotes prostate tumor growth.Purification from human milk of matriptase complexes with secreted serpins: mechanism for inhibition of matriptase other than HAI-1.The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment.Membrane-anchored serine proteases in health and disease.Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas.Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibition.Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway.Matriptase: a culprit in cancer?Matriptase expression and zymogen activation in human pilosebaceous unit.Membrane-bound serine protease inhibitor HAI-1 is required for maintenance of intestinal epithelial integrity.

P2860

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P2860

Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway

http://www.wikidata.org/entity/Q35719884

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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Coordinate expression and func ...... proteolytic signaling pathway

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Coordinate expression and func ...... proteolytic signaling pathway

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Coordinate expression and func ...... proteolytic signaling pathway

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Alana Welm

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Ami S Bhatt

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Charles S Craik

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Christopher J Farady

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Keith Wilson

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Maximiliano Vásquez

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P2860

Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates

Adhesion signaling by a novel mitotic substrate of src kinases

Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue

Inflammation and cancer

Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity

Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase

Macrophage stimulating protein (MSP) binds to its receptor via the MSP beta chain.

Proteolytic conversion of single chain precursor macrophage-stimulating protein to a biologically active heterodimer by contact enzymes of the coagulation cascade

Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk

Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential

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