Juxtamembrane autoinhibition in receptor tyrosine kinases.
about
Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane regionThe cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerizationA reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor αActivation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independentCell signaling by receptor tyrosine kinasesReceptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cellsTargeting RTK Signaling Pathways in CancerStructural and functional properties of platelet-derived growth factor and stem cell factor receptorsThe role of suppressors of cytokine signalling in human neoplasmsThe Juxtamembrane Region of the EGF Receptor Functions as an Activation DomainHomodimerization Controls the Fibroblast Growth Factor 9 Subfamily's Receptor Binding and Heparan Sulfate-Dependent Diffusion in the Extracellular MatrixStructural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin LigaseA Novel Mode of Protein Kinase Inhibition Exploiting Hydrophobic Motifs of Autoinhibited Kinases: DISCOVERY OF ATP-INDEPENDENT INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTORDesign and pharmacology of a highly specific dual FMS and KIT kinase inhibitorStructural basis for the impact of phosphorylation on the activation of plant receptor-like kinase BAK1Oncogenic RET Kinase Domain Mutations Perturb the Autophosphorylation Trajectory by Enhancing Substrate Presentation In transSteered molecular dynamics simulations reveal the likelier dissociation pathway of imatinib from its targeting kinases c-Kit and AblEvidence for intermolecular interactions between the intracellular domains of the arabidopsis receptor-like kinase ACR4, its homologs and the Wox5 transcription factorCo-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tailA change in conformational dynamics underlies the activation of Eph receptor tyrosine kinasesCharacterization of membrane protein interactions in plasma membrane derived vesicles with quantitative imaging Förster resonance energy transferAdaptability in protein structures: structural dynamics and implications in ligand design.Discoidin domain receptor functions in physiological and pathological conditions.Dynamic, structural and thermodynamic basis of insulin-like growth factor 1 kinase allostery mediated by activation loop phosphorylation.Tyrosine kinase inhibitors targeting FLT3 in the treatment of acute myeloid leukemia.Co-conserved features associated with cis regulation of ErbB tyrosine kinases.Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases.Distinct effectors of platelet-derived growth factor receptor-alpha signaling are required for cell survival during embryogenesis.Role of receptor tyrosine kinases and their ligands in glioblastoma.Mechanisms of activation of receptor tyrosine kinases: monomers or dimers.Coupling of transmembrane helix orientation to membrane release of the juxtamembrane region in FGFR3PDGFRβ signaling regulates mural cell plasticity and inhibits fat development.The Biology and Targeting of FLT3 in Pediatric Leukemia.Mutations in two putative phosphorylation motifs in the tomato pollen receptor kinase LePRK2 show antagonistic effects on pollen tube length.Cannabinoids inhibit insulin receptor signaling in pancreatic β-cells.Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosisTyrosine kinase inhibitors: Multi-targeted or single-targeted?Collagen recognition and transmembrane signalling by discoidin domain receptorsCatalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.Crystal structure of the FLT3 kinase domain bound to the inhibitor Quizartinib (AC220).
P2860
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P2860
Juxtamembrane autoinhibition in receptor tyrosine kinases.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Juxtamembrane autoinhibition in receptor tyrosine kinases.
@ast
Juxtamembrane autoinhibition in receptor tyrosine kinases.
@en
type
label
Juxtamembrane autoinhibition in receptor tyrosine kinases.
@ast
Juxtamembrane autoinhibition in receptor tyrosine kinases.
@en
prefLabel
Juxtamembrane autoinhibition in receptor tyrosine kinases.
@ast
Juxtamembrane autoinhibition in receptor tyrosine kinases.
@en
P2860
P356
P1476
Juxtamembrane autoinhibition in receptor tyrosine kinases
@en
P2093
Stevan R Hubbard
P2860
P2888
P304
P356
10.1038/NRM1399
P577
2004-06-01T00:00:00Z