FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway - Wikidata - awgldk - TriplyDB

FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway

FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway

http://www.wikidata.org/entity/Q35801606

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CtIP is required to initiate replication-dependent interstrand crosslink repair FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2 A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair Susceptibility pathways in Fanconi's anemia and breast cancer How the fanconi anemia pathway guards the genome Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway Exploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer Therapy The Fanconi anemia pathway and DNA interstrand cross-link repair Fanconi anemia and the cell cycle: new perspectives on aneuploidy Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair Pathway Structural Analysis of Human FANCL, the E3 Ligase in the Fanconi Anemia Pathway The DNA Damage Response: Making It Safe to Play with Knives FANCI protein binds to DNA and interacts with FANCD2 to recognize branched structures Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights Fanconi anaemia and the repair of Watson and Crick DNA crosslinks Expanded roles of the Fanconi anemia pathway in preserving genomic stability ATR-dependent phosphorylation of FANCM at serine 1045 is essential for FANCM functions.Fanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction.The role of the Fanconi anemia network in the response to DNA replication stress.Fanconi anemia proteins and their interacting partners: a molecular puzzle Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA.The genetic and biochemical basis of FANCD2 monoubiquitination FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair.Correct mRNA processing at a mutant TT splice donor in FANCC ameliorates the clinical phenotype in patients and is enhanced by delivery of suppressor U1 snRNAs.The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia.Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response.Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance.Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair The Fanconi anemia pathway and ICL repair: implications for cancer therapy.TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.Coordinate nuclear targeting of the FANCD2 and FANCI proteins via a FANCD2 nuclear localization signal.Regulation of the Fanconi anemia pathway by a SUMO-like delivery network Defective FANCI binding by a fanconi anemia-related FANCD2 mutant.Rescue of replication failure by Fanconi anaemia proteins.FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2

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FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway

http://www.wikidata.org/entity/Q35801606

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2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

FANCI phosphorylation function ...... on the Fanconi anemia pathway

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FANCI phosphorylation function ...... on the Fanconi anemia pathway

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FANCI phosphorylation function ...... on the Fanconi anemia pathway

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FANCI phosphorylation function ...... on the Fanconi anemia pathway

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FANCI phosphorylation function ...... on the Fanconi anemia pathway

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FANCI phosphorylation function ...... on the Fanconi anemia pathway

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Nature Structural & Molecular Biology

P1476

FANCI phosphorylation function ...... on the Fanconi anemia pathway

@en

P2093

Aiko Kinomura

http://www.w3.org/2001/XMLSchema#string

Eiji Kinoshita

http://www.w3.org/2001/XMLSchema#string

Emi Uchida

http://www.w3.org/2001/XMLSchema#string

Emiko Kinoshita-Kikuta

http://www.w3.org/2001/XMLSchema#string

Hiroyuki Kitao

http://www.w3.org/2001/XMLSchema#string

Masamichi Ishiai

http://www.w3.org/2001/XMLSchema#string

Satoshi Tashiro

http://www.w3.org/2001/XMLSchema#string

Stephen J Elledge

http://www.w3.org/2001/XMLSchema#string

Tohru Koike

http://www.w3.org/2001/XMLSchema#string

P2860

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation

FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway

FANCI is a second monoubiquitinated member of the Fanconi anemia pathway

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation

A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M

Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

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P304

1138-1146

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scholarly article

P356

10.1038/NSMB.1504

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11

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P478

15

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Agata Smogorzewska

Alihossein Saberi

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2008-10-19T00:00:00Z

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23395267

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18931676

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P921

phosphorylation

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3293454

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