Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies - Wikidata - awgldk - TriplyDB

Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies

Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies

http://www.wikidata.org/entity/Q35829548

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Implications of glial nitric oxide in neurodegenerative diseases Inflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link?C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease.Synthetic Proteins and Peptides for the Direct Interrogation of α-Synuclein Posttranslational Modifications Striatal neuroinflammation promotes Parkinsonism in rats Oxidation enhances human serum albumin thermal stability and changes the routes of amyloid fibril formation When is mass spectrometry combined with affinity approaches essential? A case study of tyrosine nitration in proteins.Evaluation of alpha-synuclein immunohistochemical methods used by invited experts Protein nitration in a mouse model of familial amyotrophic lateral sclerosis: possible multifunctional role in the pathogenesis.alpha-Synuclein affects the MAPK pathway and accelerates cell death.Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases.Tyrosine nitration impairs mammalian aldolase A activity.Iron metabolism in Parkinsonian syndromes.Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein.Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.Detection and characterization of in vivo nitration and oxidation of tryptophan residues in proteins Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice Towards translational therapies for multiple system atrophy Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease.Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy The neuropathology, pathophysiology and genetics of multiple system atrophy.α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer The regulation of catalase activity by PPAR γ is affected by α-synuclein.Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation.Neuroprotective effect of 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxy-β-D-pyranoside against sodium nitroprusside-induced neurotoxicity in HT22 cells.Genetic players in multiple system atrophy: unfolding the nature of the beast.Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease.Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease.Nonselenium glutathione peroxidase in human brain : elevated levels in Parkinson's disease and dementia with lewy bodies Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies.Nitration of tau protein is linked to neurodegeneration in tauopathies The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease.Proteins as biomarkers of oxidative/nitrosative stress in diseases: the contribution of redox proteomics.Challenging conventional wisdom: the etiologic role of dopamine oxidative stress in Parkinson's disease.Age-related changes in dopamine transporters and accumulation of 3-nitrotyrosine in rhesus monkey midbrain dopamine neurons: relevance in selective neuronal vulnerability to degeneration Spontaneous murine neuroaxonal dystrophy: a model of infantile neuroaxonal dystrophy.Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo.Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial Amyloid Pathology and genetics of multiple system atrophy: an approach to determining genetic susceptibility spectrum.Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.

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P2860

Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies

http://www.wikidata.org/entity/Q35829548

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2000 nî lūn-bûn

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Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies

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Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies

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Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies

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Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies

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Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies

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Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies

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The American Journal of Pathology

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Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies

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B I Giasson

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H I Hurtig

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H Ischiropoulos

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J E Duda

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J Q Trojanowski

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M B Stern

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Q Chen

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S M Gollomp

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V M Lee

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P2860

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

Alpha-synuclein in Lewy bodies

Alpha synuclein in neurodegenerative disorders: murderer or accomplice?

Immunoelectron-microscopic demonstration of NACP/alpha-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies

NACP/alpha-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy

Nitration of unsaturated fatty acids by nitric oxide-derived reactive nitrogen species peroxynitrite, nitrous acid, nitrogen dioxide, and nitronium ion

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

Widespread alterations of alpha-synuclein in multiple system atrophy

Epitope map of neurofilament protein domains in cortical and peripheral nervous system Lewy bodies.

Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia.

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neurodegeneration

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