Macromolecular complexes regulating cardiac ryanodine receptor function.
about
Calsequestrin 2 and arrhythmiasDefective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunctionIn cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin bindingProtein protein interactions between triadin and calsequestrin are involved in modulation of sarcoplasmic reticulum calcium release in cardiac myocytesFRET-based mapping of calmodulin bound to the RyR1 Ca2+ release channelMolecular evolution of the junctophilin gene familyReview of novel therapeutic targets for improving heart failure treatment based on experimental and clinical studiesA network-oriented perspective on cardiac calcium signalingEarly cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel.Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmiasFunctional ryanodine receptors in the plasma membrane of RINm5F pancreatic beta-cellsThe glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex and regulate its functionFunctional groups of ryanodine receptors in rat ventricular cellsFRET detection of calmodulin binding to the cardiac RyR2 calcium release channelStudying multiprotein complexes by multisignal sedimentation velocity analytical ultracentrifugation.Dysregulated sarcoplasmic reticulum calcium release: potential pharmacological target in cardiac disease.CaMKII regulation of cardiac ryanodine receptors and inositol triphosphate receptors.Altered intracellular Ca2+ handling in heart failure.Mapping the ryanodine receptor FK506-binding protein subunit using fluorescence resonance energy transfer.Cardiac ryanodine receptor phosphorylation: target sites and functional consequencesMechanisms of Ca²+ handling in zebrafish ventricular myocytesCalcium wave signaling in cancer cellsThree-dimensional visualization of FKBP12.6 binding to an open conformation of cardiac ryanodine receptorAqueous diffusion pathways as a part of the ventricular cell ultrastructure.Couplons in rat atria form distinct subgroups defined by their molecular partners.Functional characterization of the cardiac ryanodine receptor pore-forming region.Biphasic modulation of ryanodine receptors by sulfhydryl oxidation in rat ventricular myocytesCalcium and arrhythmogenesis.Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia.Hyperphosphorylation of RyRs underlies triggered activity in transgenic rabbit model of LQT2 syndrome.Targeting cardiomyocyte Ca2+ homeostasis in heart failure.Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.Calsequestrin accumulation in rough endoplasmic reticulum promotes perinuclear Ca2+ releaseDantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia.Eavesdropping on the social lives of Ca(2+) sparksA mechanistic description of gating of the human cardiac ryanodine receptor in a regulated minimal environment.Cardiac and skeletal muscle disorders caused by mutations in the intracellular Ca2+ release channels.Luminal Ca2+ regulation of single cardiac ryanodine receptors: insights provided by calsequestrin and its mutantsEnhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts.Altered cardiac myocyte Ca regulation in heart failure.
P2860
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P2860
Macromolecular complexes regulating cardiac ryanodine receptor function.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Macromolecular complexes regulating cardiac ryanodine receptor function.
@ast
Macromolecular complexes regulating cardiac ryanodine receptor function.
@en
type
label
Macromolecular complexes regulating cardiac ryanodine receptor function.
@ast
Macromolecular complexes regulating cardiac ryanodine receptor function.
@en
prefLabel
Macromolecular complexes regulating cardiac ryanodine receptor function.
@ast
Macromolecular complexes regulating cardiac ryanodine receptor function.
@en
P1476
Macromolecular complexes regulating cardiac ryanodine receptor function
@en
P2093
Donald M Bers
P304
P356
10.1016/J.YJMCC.2004.05.026
P577
2004-08-01T00:00:00Z