Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.
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Molecular Imaging of Metabolic Reprograming in Mutant IDH CellsMetabolic reprogramming in cancer cells: glycolysis, glutaminolysis, and Bcl-2 proteins as novel therapeutic targets for cancerMetabolic consequences of oncogenic IDH mutationsMagnetic Resonance (MR) Metabolic Imaging in Glioma.Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle.Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation, supporting acetyl-coenzyme A levels.Novel type II and monomeric NAD+ specific isocitrate dehydrogenases: phylogenetic affinity, enzymatic characterization, and evolutionary implication.The Warburg effect: a balance of flux analysisThe cpk model of recessive PKD shows glutamine dependence associated with the production of the oncometabolite 2-hydroxyglutarate.Isocitrate dehydrogenase mutations in gliomasExtreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion.Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia.Fast exchange fluxes around the pyruvate node: a leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment.Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring.Decreased expression of IDH1-R132H correlates with poor survival in gastrointestinal cancer.ω-Amidase: an underappreciated, but important enzyme in L-glutamine and L-asparagine metabolism; relevance to sulfur and nitrogen metabolism, tumor biology and hyperammonemic diseases.Temperature induces significant changes in both glycolytic reserve and mitochondrial spare respiratory capacity in colorectal cancer cell lines.Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression.IDH mutations in cancer and progress toward development of targeted therapeutics.IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism.Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype.D-2-Hydroxyglutarate does not mimic all the IDH mutation effects, in particular the reduced etoposide-triggered apoptosis mediated by an alteration in mitochondrial NADH.IDH mutations in liver cell plasticity and biliary cancer.Isocitrate dehydrogenase 1 mutation subtypes at site 132 and their translational potential in glioma.Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities.Beyond Brooding on Oncometabolic Havoc in IDH-Mutant Gliomas and AML: Current and Future Therapeutic Strategies.Enhancement of angiogenic effects by hypoxia-preconditioned human umbilical cord-derived mesenchymal stem cells in a mouse model of hindlimb ischemia.Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities.D-2-Hydroxyglutarate Is Necessary and Sufficient for Isocitrate Dehydrogenase 1 Mutant-Induced MIR148A Promoter Methylation.D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization.Biological Role and Therapeutic Potential of IDH Mutations in Cancer.
P2860
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P2860
Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.
description
2014 nî lūn-bûn
@nan
2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Cancer-associated isocitrate d ...... mine metabolism under hypoxia.
@ast
Cancer-associated isocitrate d ...... mine metabolism under hypoxia.
@en
Cancer-associated isocitrate dehydrogenase 1
@nl
type
label
Cancer-associated isocitrate d ...... mine metabolism under hypoxia.
@ast
Cancer-associated isocitrate d ...... mine metabolism under hypoxia.
@en
Cancer-associated isocitrate dehydrogenase 1
@nl
prefLabel
Cancer-associated isocitrate d ...... mine metabolism under hypoxia.
@ast
Cancer-associated isocitrate d ...... mine metabolism under hypoxia.
@en
Cancer-associated isocitrate dehydrogenase 1
@nl
P2093
P2860
P356
P1476
Cancer-associated isocitrate d ...... amine metabolism under hypoxia
@en
P2093
Ali Winters
David M Gooden
Ethan Poteet
Ivan Spasojevic
Laszlo G Boros
Liang-Jun Yan
Shao-Hua Yang
P2860
P304
23318-23328
P356
10.1074/JBC.M114.575183
P407
P577
2014-07-01T00:00:00Z