The 5'HS2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally distinct NF-E2 binding sites
about
Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expressionThe accessible chromatin landscape of the human genomeA novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteinsIn vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reactionLocus control regionsThe ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogeneBeta-globin LCR and intron elements cooperate and direct spatial reorganization for gene therapyp45(NFE2) is a negative regulator of erythroid proliferation which contributes to the progression of Friend virus-induced erythroleukemiasNF-E2 disrupts chromatin structure at human beta-globin locus control region hypersensitive site 2 in vitroThe dihydrofolate reductase origin of replication does not contain any nonredundant genetic elements required for origin activity.Effect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice.Requirements for utilization of CREB binding protein by hypersensitive site two of the beta-globin locus control regionIn vivo protein-DNA interactions at hypersensitive site 3 of the human beta-globin locus control region.Pathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis.Loading of DNA-binding factors to an erythroid enhancer.p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes.Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2Erythroid-specific activity of the glycophorin B promoter requires GATA-1 mediated displacement of a repressorNuclear relocation of a transactivator subunit precedes target gene activation.Structural and functional cross-talk between a distant enhancer and the epsilon-globin gene promoter shows interdependence of the two elements in chromatin.Synthetic human beta-globin 5'HS2 constructs function as locus control regions only in multicopy transgene concatamers.The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene.Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the mammalian beta-like globin gene locusHematopoietic-specific activators establish an overlapping pattern of histone acetylation and methylation within a mammalian chromatin domain.Evaluation of beta-globin gene therapy constructs in single copy transgenic mice.The world according to MafThe 5' flanking region of the rat LAP (C/EBP beta) gene can direct high-level, position-independent, copy number-dependent expression in multiple tissues in transgenic mice.Multiple elements in human beta-globin locus control region 5' HS 2 are involved in enhancer activity and position-independent, transgene expressionRetroviral vector sequences inhibit human beta-globin gene expression in transgenic mice.Dual promoter activation by the human beta-globin locus control region.Characterization of the factors binding to a PEPCK gene upstream hypersensitive site with LCR activity.Retroviral integration within the Fli-2 locus results in inactivation of the erythroid transcription factor NF-E2 in Friend erythroleukemias: evidence that NF-E2 is essential for globin expressionStudying the recruitment of Sp1 to the beta-globin promoter with an in vivo method: protein position identification with nuclease tail (PIN*POINT)Deletion analysis of the human CD2 gene locus control region in transgenic mice.HNF4alpha and NF-E2 are key transcriptional regulators of the murine Abcc6 gene expression.A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region.The developmental regulation of the human zeta-globin gene in transgenic mice employing beta-galactosidase as a reporter gene.Structure and function of the murine beta-globin locus control region 5' HS-3.Synergism between hypersensitive sites confers long-range gene activation by the beta-globin locus control region.
P2860
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P2860
The 5'HS2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally distinct NF-E2 binding sites
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
The 5'HS2 of the globin locus ...... y distinct NF-E2 binding sites
@ast
The 5'HS2 of the globin locus ...... y distinct NF-E2 binding sites
@en
type
label
The 5'HS2 of the globin locus ...... y distinct NF-E2 binding sites
@ast
The 5'HS2 of the globin locus ...... y distinct NF-E2 binding sites
@en
prefLabel
The 5'HS2 of the globin locus ...... y distinct NF-E2 binding sites
@ast
The 5'HS2 of the globin locus ...... y distinct NF-E2 binding sites
@en
P2860
P1433
P1476
The 5'HS2 of the globin locus ...... y distinct NF-E2 binding sites
@en
P2093
P2860
P304
P407
P577
1991-06-01T00:00:00Z