Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.
about
Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substratesAn alternative form of replication protein a expressed in normal human tissues supports DNA repairYeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinaseATR: an essential regulator of genome integrityTipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling.Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway.Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks.The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA.ATRIP from TopBP1 to ATR--in vitro activation of a DNA damage checkpoint.New insights into checkpoint kinase 1 in the DNA damage response signaling network.In vitro analysis of the role of replication protein A (RPA) and RPA phosphorylation in ATR-mediated checkpoint signalingSwi1 associates with chromatin through the DDT domain and recruits Swi3 to preserve genomic integrity.Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1)Tousled-like kinase-dependent phosphorylation of Rad9 plays a role in cell cycle progression and G2/M checkpoint exit.TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution.RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling.RNA polymerase: the most specific damage recognition protein in cellular responses to DNA damage?DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP.Bringing It All Together: Coupling Excision Repair to the DNA Damage Checkpoint.DNA damage-induced ATM- and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH).Probing the Mec1ATR Checkpoint Activation Mechanism with Small Peptides.Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machineryATR Kinase Inhibition Protects Non-cycling Cells from the Lethal Effects of DNA Damage and Transcription Stress.Direct role for the replication protein treslin (Ticrr) in the ATR kinase-mediated checkpoint responseFormation of Arabidopsis Cryptochrome 2 photobodies in mammalian nuclei: application as an optogenetic DNA damage checkpoint switchCooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA.A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1.Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase.The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms.Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system.Cell-cycle-specific activators of the Mec1/ATR checkpoint kinase.Transcription-induced DNA toxicity at trinucleotide repeats: double bubble is trouble.PostExcision Events in Human Nucleotide Excision Repair.Changing of the guard: how ATM hands off DNA double-strand break signaling to ATR.Intramolecular Binding of the Rad9 C Terminus in the Checkpoint Clamp Rad9-Hus1-Rad1 Is Closely Linked with Its DNA Binding.ATR and MKP1 play distinct roles in response to UV-B stress in Arabidopsis.Genotoxicity of fine and coarse fraction ambient particulate matter in immortalised normal (TT1) and cancer-derived (A549) alveolar epithelial cells.Roles of UVA radiation and DNA damage responses in melanoma pathogenesis.
P2860
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P2860
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.
@ast
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.
@en
type
label
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.
@ast
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.
@en
prefLabel
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.
@ast
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.
@en
P2860
P356
P1476
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.
@en
P2093
Jun-Hyuk Choi
Laura A Lindsey-Boltz
P2860
P304
13301-13306
P356
10.1073/PNAS.0706013104
P407
P50
P577
2007-08-08T00:00:00Z