The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms.
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Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substratesStructure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1Slx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks.Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitmentGenetic instability in budding and fission yeast-sources and mechanismsSensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerase εPhosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpointRad4 mainly functions in Chk1-mediated DNA damage checkpoint pathway as a scaffold protein in the fission yeast Schizosaccharomyces pombeActivation of the ATR kinase by the RPA-binding protein ETAA1ETAA1 acts at stalled replication forks to maintain genome integrityAssembly of Slx4 signaling complexes behind DNA replication forksPreserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance.ATRIP from TopBP1 to ATR--in vitro activation of a DNA damage checkpoint.The Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner.HERC2-USP20 axis regulates DNA damage checkpoint through Claspin.Cdc5 blocks in vivo Rad53 activity, but not in situ activity (ISA).Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner.Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1.An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanismPhosphoproteomics reveals distinct modes of Mec1/ATR signaling during DNA replicationRegulation of Mec1 kinase activity by the SWI/SNF chromatin remodeling complexThr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase.Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase.RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling.The unstructured C-terminal tail of yeast Dpb11 (human TopBP1) protein is dispensable for DNA replication and the S phase checkpoint but required for the G2/M checkpoint.Leveraging DNA damage response signaling to identify yeast genes controlling genome stability.Colocalization of Mec1 and Mrc1 is sufficient for Rad53 phosphorylation in vivo.Yet another job for Dna2: Checkpoint activation.RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response.Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint.Probing the Mec1ATR Checkpoint Activation Mechanism with Small Peptides.Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machineryATR signalling: more than meeting at the fork.Direct role for the replication protein treslin (Ticrr) in the ATR kinase-mediated checkpoint responseCoupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system.The Intra-S Checkpoint Responses to DNA Damage.ATR: a master conductor of cellular responses to DNA replication stress.Cell-cycle-specific activators of the Mec1/ATR checkpoint kinase.Eukaryotic DNA damage checkpoint activation in response to double-strand breaks.
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The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The unstructured C-terminal ta ...... R via two distinct mechanisms.
@en
The unstructured C-terminal ta ...... R via two distinct mechanisms.
@nl
type
label
The unstructured C-terminal ta ...... R via two distinct mechanisms.
@en
The unstructured C-terminal ta ...... R via two distinct mechanisms.
@nl
prefLabel
The unstructured C-terminal ta ...... R via two distinct mechanisms.
@en
The unstructured C-terminal ta ...... R via two distinct mechanisms.
@nl
P2860
P1433
P1476
The unstructured C-terminal ta ...... R via two distinct mechanisms.
@en
P2093
Peter M Burgers
Vasundhara M Navadgi-Patil
P2860
P304
P356
10.1016/J.MOLCEL.2009.10.014
P577
2009-12-01T00:00:00Z