A novel function of eIF2alpha kinases as inducers of the phosphoinositide-3 kinase signaling pathway - Wikidata - awgldk - TriplyDB

A novel function of eIF2alpha kinases as inducers of the phosphoinositide-3 kinase signaling pathway

A novel function of eIF2alpha kinases as inducers of the phosphoinositide-3 kinase signaling pathway

http://www.wikidata.org/entity/Q35949097

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6-Shogaol induces apoptosis in human hepatocellular carcinoma cells and exhibits anti-tumor activity in vivo through endoplasmic reticulum stress The chemotherapeutic drug 5-fluorouracil promotes PKR-mediated apoptosis in a p53-independent manner in colon and breast cancer cells ChIP-Seq Data Mining: Remarkable Differences in NRSF/REST Target Genes between Human ESC and ESC-Derived Neurons Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α.Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.A critical role for mTORC1 in erythropoiesis and anemia.Wogonin induced calreticulin/annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner.Endoplasmic reticulum stress and the unfolded protein response in nonalcoholic fatty liver disease.Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver.PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation Dimethyl sulfoxide reduces hepatocellular lipid accumulation through autophagy induction.The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer.PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma.The protein activator of protein kinase R, PACT/RAX, negatively regulates protein kinase R during mouse anterior pituitary development.Therapeutic interventions to disrupt the protein synthetic machinery in melanoma ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies.Endoplasmic reticulum stress induces PRNP prion protein gene expression in breast cancer.Stress and IGF-I differentially control cell fate through mammalian target of rapamycin (mTOR) and retinoblastoma protein (pRB)Neuronal human BACE1 knockin induces systemic diabetes in mice.PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells PERK-dependent regulation of IAP translation during ER stress.Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia.Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis.Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response.Non-alcoholic steatohepatitis and hepatocellular carcinoma: implications for lycopene intervention.High-refined-carbohydrate and high-fat diets induce comparable hepatic tumorigenesis in male mice.Control of oncogenesis by eIF2α phosphorylation: implications in PTEN and PI3K-Akt signaling and tumor treatment.Sorafenib, a multikinase inhibitor, induces formation of stress granules in hepatocarcinoma cells.The human parasite Leishmania amazonensis downregulates iNOS expression via NF-κB p50/p50 homodimer: role of the PI3K/Akt pathway.The integrated stress response.Development of transgenic mice expressing a conditionally active form of the eIF2α kinase PKR.eIF2α kinases control chalone production in Dictyostelium discoideum.Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death.Negative regulation of mTORC2 by glycogen synthase kinase-3β: an adaptive process to stress with an anticancer therapeutic potential?Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway Fatty acid-mediated endoplasmic reticulum stress in vivo: differential response to the infusion of Soybean and Lard Oil in rats.PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2alpha phosphorylation.The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53.

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A novel function of eIF2alpha kinases as inducers of the phosphoinositide-3 kinase signaling pathway

http://www.wikidata.org/entity/Q35949097

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

A novel function of eIF2alpha ...... ide-3 kinase signaling pathway

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A novel function of eIF2alpha ...... ide-3 kinase signaling pathway

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A novel function of eIF2alpha ...... ide-3 kinase signaling pathway

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A novel function of eIF2alpha ...... ide-3 kinase signaling pathway

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A novel function of eIF2alpha ...... ide-3 kinase signaling pathway

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MBC.E07-01-0053

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Molecular Biology of the Cell

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A novel function of eIF2alpha ...... ide-3 kinase signaling pathway

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Antonis E Koromilas

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Dionissios Baltzis

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Jennifer F Raven

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Jerry Pelletier

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Jothi-Latha Krishnamoorthy

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Olivier Pluquet

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Shirin Kazemi

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Shuo Wang

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Zineb Mounir

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P2860

The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.

Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways

Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase.

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

Initiation of Protein Synthesis by Hepatitis C Virus Is Refractory to Reduced eIF2 {middle dot} GTP {middle dot} Met-tRNAiMet Ternary Complex Availability

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

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3635-3644

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scholarly article

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10.1091/MBC.E07-01-0053

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9

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18

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2007-06-27T00:00:00Z

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6240061

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17596516

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1951772

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