Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis - Wikidata - awgldk - TriplyDB

Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis

Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis

http://www.wikidata.org/entity/Q35951468

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Mitochondrial dysfunction in ataxia-telangiectasia Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions Nucleotide salvage deficiencies, DNA damage and neurodegeneration Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome Signal transduction by reactive oxygen species A novel mouse model for ataxia-telangiectasia with a N-terminal mutation displays a behavioral defect and a low incidence of lymphoma but no increased oxidative burden.Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation Mitochondrial translocation of p53 modulates neuronal fate by preventing differentiation-induced mitochondrial stress.Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice.Signal transduction by mitochondrial oxidants.DNA double-strand breaks activate ATM independent of mitochondrial dysfunction in A549 cells Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia.DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome Increases in mitochondrial DNA content and 4977-bp deletion upon ATM/Chk2 checkpoint activation in HeLa cells.Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism.Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice.Methotrexate inhibits NF-κB activity via long intergenic (noncoding) RNA-p21 induction Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes Ataxia telangiectasia mutated influences cytochrome c oxidase activity.SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs.Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling.Tug of war between survival and death: exploring ATM function in cancer.Investigation of tRNA and ATPase 6/8 gene mutations in Iranian ataxia telangiectasia patients.Mitochondrial respiration protects against oxygen-associated DNA damage.Rad53 is essential for a mitochondrial DNA inheritance checkpoint regulating G1 to S progression.MEK2 regulates ribonucleotide reductase activity through functional interaction with ribonucleotide reductase small subunit p53R2.Expression and maintenance of mitochondrial DNA: new insights into human disease pathology ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts Induced pluripotent stem cells from ataxia-telangiectasia recapitulate the cellular phenotype.Maintenance of mitochondrial DNA by the Caenorhabditis elegans ATR checkpoint protein ATL-1.The ataxia telangiectasia mutated kinase pathway regulates IL-23 expression by human dendritic cells ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα.Cell cycle- and ribonucleotide reductase-driven changes in mtDNA copy number influence mtDNA Inheritance without compromising mitochondrial gene expression.Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling.

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Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis

http://www.wikidata.org/entity/Q35951468

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

Ataxia-telangiectasia mutated ...... and mitochondrial homeostasis

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Ataxia-telangiectasia mutated ...... and mitochondrial homeostasis

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type

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Ataxia-telangiectasia mutated ...... and mitochondrial homeostasis

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Ataxia-telangiectasia mutated ...... and mitochondrial homeostasis

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prefLabel

Ataxia-telangiectasia mutated ...... and mitochondrial homeostasis

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Ataxia-telangiectasia mutated ...... and mitochondrial homeostasis

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Journal of Clinical Investigation

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Ataxia-telangiectasia mutated ...... and mitochondrial homeostasis

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Alan C Sartorelli

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Gerald S Shadel

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Jana S Eaton

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Nicholas D Bonawitz

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Z Ping Lin

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P2860

Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity

Differential involvement of the related DNA helicases Pif1p and Rrm3p in mtDNA point mutagenesis and stability.

Aconitase couples metabolic regulation to mitochondrial DNA maintenance.

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits

ATM: genome stability, neuronal development, and cancer cross paths

The many substrates and functions of ATM

p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint

Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells

Mitochondrial DNA depletion and dGK gene mutations

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2723-2734

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10.1172/JCI31604

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9

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117

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1952633

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