The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system.
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Origins of amyloid-βCerebrospinal fluid peptides as potential Parkinson disease biomarkers: a staged pipeline for discovery and validation.Peptide fingerprinting of Alzheimer's disease in cerebrospinal fluid: identification and prospective evaluation of new synaptic biomarkersAlternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction.Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.Peptidome analysis of cerebrospinal fluid by LC-MALDI MSBiomarkers of Alzheimer's disease: from central nervous system to periphery?Turnover of amyloid precursor protein family members determines their nuclear signaling capabilityImpact of cerebrospinal fluid shunting for idiopathic normal pressure hydrocephalus on the amyloid cascade.Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system.Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer's DiseaseA correlativity study of plasma APL1β28 and clusterin levels with MMSE/MoCA/CASI in aMCI patients.Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.APLP1 as a cerebrospinal fluid biomarker for γ-secretase modulator treatmentPresenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease.A single dose of the γ-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in humans.The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy VolunteersAmyloid mis-metabolism in idiopathic normal pressure hydrocephalus.Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase.The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyondγ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid β-Protein ProductionRedundancy and divergence in the amyloid precursor protein family.Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase.γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.A surrogate marker for Abeta42 production in the CNS.APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding.Age-related modulation of γ-secretase activity in non-human primate brains.APLP1 promotes dFoxO-dependent cell death in Drosophila.Biomarkers and Alzheimer spectrum.Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease
P2860
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P2860
The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
The 28-amino acid form of an A ...... in the central nervous system.
@ast
The 28-amino acid form of an A ...... in the central nervous system.
@en
type
label
The 28-amino acid form of an A ...... in the central nervous system.
@ast
The 28-amino acid form of an A ...... in the central nervous system.
@en
prefLabel
The 28-amino acid form of an A ...... in the central nervous system.
@ast
The 28-amino acid form of an A ...... in the central nervous system.
@en
P2093
P2860
P50
P356
P1476
The 28-amino acid form of an A ...... in the central nervous system.
@en
P2093
Harald Steiner
Haruhiko Akiyama
Hiroaki Kazui
Jingwei Jiang
Kanta Yanagida
Kensaku Kasuga
Kentaro Deguchi
Kouhei Nishitomi
Masaki Ikeda
Masaki Kondo
P2860
P304
P356
10.1002/EMMM.200900026
P577
2009-07-01T00:00:00Z