about
Sumoylation of eIF4E activates mRNA translation4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferationActivation and function of the MAPKs and their substrates, the MAPK-activated protein kinasesmTOR: from growth signal integration to cancer, diabetes and ageingRegulation of global and specific mRNA translation by the mTOR signaling pathwaySignalling to eIF4E in cancerThe La-Related Proteins, a Family with Connections to CancerAmino acid management in cancerMnk kinase pathway: Cellular functions and biological outcomesAmino acids and mTORC1: from lysosomes to diseaseRegulation of translation initiation in eukaryotes: mechanisms and biological targetsVersatility of RNA-Binding Proteins in CancerA novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformationeIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcriptionCotargeting MNK and MEK kinases induces the regression of NF1-mutant cancersThe mechanism of eukaryotic translation initiation and principles of its regulationPlakophilin-associated RNA-binding proteins in prostate cancer and their implications in tumor progression and metastasis.PI3K and cancer: lessons, challenges and opportunitiesThe sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement.A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).Activation of host translational control pathways by a viral developmental switchPhosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissuesCell cycle progression or translation control is not essential for vesicular stomatitis virus oncolysis of hepatocellular carcinoma.Enhancing mTOR-targeted cancer therapy.Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E.Mouse models of cancer as biological filters for complex genomic data.Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells.Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XLExtracellular signal-regulated kinase positively regulates the oncogenic activity of MCT-1 in diffuse large B-cell lymphoma.Targeting the translational machinery as a novel treatment strategy for hematologic malignanciesGlobal signatures of protein and mRNA expression levels.Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTORMnk earmarks eIF4E for cancer therapy.Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression.Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1.TOR signaling never gets old: aging, longevity and TORC1 activity.Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.Translation initiation factor eIF4F modifies the dexamethasone response in multiple myelomaIdentification of a gene expression driven progression pathway in myxoid liposarcoma.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Dissecting eIF4E action in tumorigenesis
@ast
Dissecting eIF4E action in tumorigenesis
@en
type
label
Dissecting eIF4E action in tumorigenesis
@ast
Dissecting eIF4E action in tumorigenesis
@en
prefLabel
Dissecting eIF4E action in tumorigenesis
@ast
Dissecting eIF4E action in tumorigenesis
@en
P2093
P2860
P356
P1433
P1476
Dissecting eIF4E action in tumorigenesis
@en
P2093
Abba Malina
Hans-Guido Wendel
Jerry Pelletier
John R Mills
Ricardo L A Silva
Rie Watanabe-Fukunaga
Rikiro Fukunaga
Scott W Lowe
Takeshi Ueda
P2860
P304
P356
10.1101/GAD.1604407
P577
2007-11-30T00:00:00Z