Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases - Wikidata - awgldk - TriplyDB

Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases

Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases

http://www.wikidata.org/entity/Q28246409

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Stable isotope-resolved metabolomics and applications for drug development Dysregulated metabolism contributes to oncogenesis Two-way communication between the metabolic and cell cycle machineries: the molecular basis Cell cycle regulators guide mitochondrial activity in radiation-induced adaptive response Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells Therapeutic targeting of replicative immortality 6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27 Progestins activate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cells Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells Sustained proliferation in cancer: Mechanisms and novel therapeutic targets PFK15, a Small Molecule Inhibitor of PFKFB3, Induces Cell Cycle Arrest, Apoptosis and Inhibits Invasion in Gastric Cancer Adapting glycolysis to cancer cell proliferation: the MAPK pathway focuses on PFKFB3: Figure 1 Analysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma.Loss of PFKFB4 induces cell death in mitotically arrested ovarian cancer cells First siRNA library screening in hard-to-transfect HUVEC cells.E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases Endothelial PFKFB3 plays a critical role in angiogenesis.PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli.MAPK14/p38α-dependent modulation of glucose metabolism affects ROS levels and autophagy during starvation.Subcellular proteomics reveals a role for nucleo-cytoplasmic trafficking at the DNA replication origin activation checkpoint Spatial distribution of cellular function: the partitioning of proteins between mitochondria and the nucleus in MCF7 breast cancer cells Systematic nucleo-cytoplasmic trafficking of proteins following exposure of MCF7 breast cancer cells to estradiol.Cell metabolism sets the differences between subpopulations of satellite cells (SCs).The p160/steroid receptor coactivator family: potent arbiters of uterine physiology and dysfunction ER Alpha Rapid Signaling Is Required for Estrogen Induced Proliferation and Migration of Vascular Endothelial Cells.Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor.Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons.Insulin-like growth factor binding protein-3 is a new predictor of radiosensitivity on esophageal squamous cell carcinoma.Dose-dependent effects of gamma radiation on the early zebrafish development and gene expression Type 2 Diabetes Dysregulates Glucose Metabolism in Cardiac Progenitor Cells p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway.Is there a link between soft drinks and erectile dysfunction?Tumor glycolysis as a target for cancer therapy: progress and prospects.Glucose and glutamine metabolism control by APC and SCF during the G1-to-S phase transition of the cell cycle.Regulation of mammalian nucleotide metabolism and biosynthesis Pheochromocytoma: Gasping for Air.Glucose induces protein targeting to glycogen in hepatocytes by fructose 2,6-bisphosphate-mediated recruitment of MondoA to the promoter.Sertoli-secreted FGF-2 induces PFKFB4 isozyme expression in mouse spermatogenic cells by activation of the MEK/ERK/CREB pathway.

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Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases

http://www.wikidata.org/entity/Q28246409

description

2009 nî lūn-bûn

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2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Nuclear targeting of 6-phospho ...... n via cyclin-dependent kinases

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Nuclear targeting of 6-phospho ...... n via cyclin-dependent kinases

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Nuclear targeting of 6-phospho ...... n via cyclin-dependent kinases

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Nuclear targeting of 6-phospho ...... n via cyclin-dependent kinases

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Nuclear targeting of 6-phospho ...... n via cyclin-dependent kinases

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Nuclear targeting of 6-phospho ...... n via cyclin-dependent kinases

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Nuclear targeting of 6-phospho ...... n via cyclin-dependent kinases

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JBC.M109.016816

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Journal of Biological Chemistry

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Nuclear targeting of 6-phospho ...... n via cyclin-dependent kinases

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Alan Simmons

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Amy L Clem

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Andrew Lane

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Binks Wattenberg

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Brian F Clem

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Deanna Siow

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Erin Brock

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Jason Chesney

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Kristin Nelson

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Sucheta Telang

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A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators.

Brick by brick: metabolism and tumor cell growth

Fructose-2,6-bisphosphate and control of carbohydrate metabolism in eukaryotes

Regulation of ubiquitous 6-phosphofructo-2-kinase by the ubiquitin-proteasome proteolytic pathway during myogenic C2C12 cell differentiation

Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain

High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers

Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27

Characterization of a human placental fructose-6-phosphate, 2-kinase/fructose-2,6-bisphosphatase

Roles for fructose-2,6-bisphosphate in the control of fuel metabolism: beyond its allosteric effects on glycolytic and gluconeogenic enzymes

Cell cycle kinases in cancer

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3344521

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10.1074/JBC.M109.016816

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36

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284

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Abdullah Yalcin

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19473963

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