Reconstitution of functional interleukin 2 receptor complexes on fibroblastoid cells: involvement of the cytoplasmic domain of the gamma chain in two distinct signaling pathways
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Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growthDefective human interleukin 2 receptor gamma chain in an atypical X chromosome-linked severe combined immunodeficiency with peripheral T cellsUtilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) miceGrf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LATInvolvement of Hgs/Hrs in signaling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1Functional analysis of the human interleukin 2 receptor gamma chain gene promoterPyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathwayThe molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexesJanus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice.Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylationActivation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.Growth factors can enhance lymphocyte survival without committing the cell to undergo cell division.Blockade of T- and B-lymphocyte development by antibody to the gamma c subunit of the receptors for interleukins 2, 4, and 7Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains.The interleukin (IL)-2 family cytokines: survival and proliferation signaling pathways in T lymphocytes.Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferation.CD3+CD16+NK1.1+B220+ large granular lymphocytes arise from both alpha-beta TCR+CD4-CD8- and gamma-delta TCR+CD4-CD8- cells.Interleukin 2 receptor gamma chain expression on resting and activated lymphoid cellsThe roles for cytokines in the generation and maintenance of regulatory T cells.Configuration of the interferon-alpha/beta receptor complex determines the context of the biological response.Differential regulation of the expression of interleukin-2 receptor gamma-chain during the in vitro differentiation of human myeloid cells.Mouse interleukin-2 receptor alpha gene expression. Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements.Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.The common γ-chain cytokine receptor: tricks-and-treats for T cells.Acetylation Modulates IL-2 Receptor Signaling in T Cells.A membrane-proximal region of the interleukin-2 receptor gamma c chain sufficient for Jak kinase activation and induction of proliferation in T cells.Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction.Interaction of STAT5 dimers on two low affinity binding sites mediates interleukin 2 (IL-2) stimulation of IL-2 receptor alpha gene transcription.An interleukin (IL)-13 receptor lacking the cytoplasmic domain fails to transduce IL-13-induced signals and inhibits responses to IL-4.Analysis of IL-2, IL-4 and their receptors in clonally-related cell lines derived from a patient with a progressive cutaneous T-cell lymphoproliferative disorder.Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the beta chain and non-tyrosine residues of the gamma c chain.The action of interleukin-2 receptor subunits defines a new type of signaling mechanism for hematopoietin receptors in hepatic cells and fibroblasts.Erythropoietin and interleukin-2 activate distinct JAK kinase family members.Interleukin 2-induced activation of JAK3: possible involvement in signal transduction for c-myc induction and cell proliferation.Evidence for a critical role for the cytoplasmic region of the interleukin 2 (IL-2) receptor gamma chain in IL-2, IL-4, and IL-7 signallingHuman hematopoietic cell express two forms of the cytokine receptor common gamma-chain (gamma c).Expression of IL-2 receptor beta and gamma chains by human gingival fibroblasts and up-regulation of adhesion to neutrophils in response to IL-2.
P2860
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P2860
Reconstitution of functional interleukin 2 receptor complexes on fibroblastoid cells: involvement of the cytoplasmic domain of the gamma chain in two distinct signaling pathways
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Reconstitution of functional i ...... wo distinct signaling pathways
@ast
Reconstitution of functional i ...... wo distinct signaling pathways
@en
type
label
Reconstitution of functional i ...... wo distinct signaling pathways
@ast
Reconstitution of functional i ...... wo distinct signaling pathways
@en
prefLabel
Reconstitution of functional i ...... wo distinct signaling pathways
@ast
Reconstitution of functional i ...... wo distinct signaling pathways
@en
P2093
P2860
P356
P1476
Reconstitution of functional i ...... wo distinct signaling pathways
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.9.4127
P407
P577
1993-05-01T00:00:00Z