Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis. - Wikidata - awgldk - TriplyDB

Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis.

Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis.

http://www.wikidata.org/entity/Q36323476

about

Functional amyloid formation within mammalian tissue.The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition Amino acid sequence determinants in self-assembly of insulin chiral amyloid superstructures: role of C-terminus of B-chain in association of fibrils Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes Epitope mapping of the melanosomal matrix protein gp100 (PMEL17): rapid processing in the endoplasmic reticulum and glycosylation in the early Golgi compartment The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis Biogenesis and function of multivesicular bodies Melanosomes--dark organelles enlighten endosomal membrane transport Amyloids: friend or foe?Protein Folding and Mechanisms of Proteostasis PMEL Amyloid Fibril Formation: The Bright Steps of Pigmentation BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor Physiological factors that regulate skin pigmentation High-resolution MAS NMR analysis of PI3-SH3 amyloid fibrils: backbone conformation and implications for protofilament assembly and structure .MHC class II presentation of gp100 epitopes in melanoma cells requires the function of conventional endosomes and is influenced by melanosomes.Electron tomography of early melanosomes: implications for melanogenesis and the generation of fibrillar amyloid sheets.Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs Aggregation prone regions in human proteome: Insights from large-scale data analyses.Quartz crystal microbalance studies of multilayer glucagon fibrillation at the solid-liquid interface The Surprising Role of Amyloid Fibrils in HIV Infection The secreted form of a melanocyte membrane-bound glycoprotein (Pmel17/gp100) is released by ectodomain shedding.Ubiquitylation of a melanosomal protein by HECT-E3 ligases serves as sorting signal for lysosomal degradation.Endoplasmic reticulum export, subcellular distribution, and fibril formation by Pmel17 require an intact N-terminal domain junction.Glycoprotein nonmetastatic melanoma protein b, a melanocytic cell marker, is a melanosome-specific and proteolytically released protein.Signaling pathways in melanosome biogenesis and pathology Two SNPs in the SILV gene are associated with silver coat colour in ponies.Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenic Key role of CRF in the skin stress response system.Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17.The prion hypothesis: from biological anomaly to basic regulatory mechanism.Defining the limits: Protein aggregation and toxicity in vivo The Dominant white, Dun and Smoky color variants in chicken are associated with insertion/deletion polymorphisms in the PMEL17 gene Myosin vc interacts with Rab32 and Rab38 proteins and works in the biogenesis and secretion of melanosomes Repeat domains of melanosome matrix protein Pmel17 orthologs form amyloid fibrils at the acidic melanosomal pH.Proprotein convertases process Pmel17 during secretion.Evolutionary, physicochemical, and functional mechanisms of protein homooligomerization.Reduced glutathione disrupts the intracellular trafficking of tyrosinase and tyrosinase-related protein-1 but not dopachrome tautomerase and Pmel17 to melanosomes, which results in the attenuation of melanization.Dual loss of ER export and endocytic signals with altered melanosome morphology in the silver mutation of Pmel17 Structural insights into functional and pathological amyloid.Amyloidogenic properties of a D/N mutated 12 amino acid fragment of the C-terminal domain of the Cholesteryl-Ester Transfer Protein (CETP).

P2860

Q21092782-2020C9D6-990C-4D13-A9EE-EC5EE866F207 Q24311263-668BE706-8B3C-40E6-8B7F-97CB84700D7C Q24318123-58249CB5-6EED-4472-BEBC-5632F396F382 Q24323356-373331B2-9477-4849-B021-969AE9B881E0 Q24337303-CC218033-D91A-4846-B44D-D5812075076D Q24338990-523F64F7-A1EB-47C6-B901-5E164116100F Q24601502-B827E250-7C79-4A9C-B9BB-4A2CB0B7A5DC Q24647195-9D339CD3-400E-408F-9ADC-36BC15328E29 Q24653554-2F091D62-1652-44F9-BE79-FAAC646492D9 Q26801512-F8BF1179-B699-46C4-85D9-BEB27DD80C73 Q28076932-035BF497-4B61-49E1-915E-327FF9C77ED8 Q28117259-3D84081F-3626-4546-B077-AC66CD0D1D9E Q28245280-F5B9D6C1-E634-4E4A-AD34-71CB94040DC0 Q30156069-52AECE24-8F50-4C72-8EA8-CD6232332D92 Q30437794-876A66EC-13EC-44D5-9761-37EF4823F84D Q30485074-94F61E66-924C-4DC1-AAA7-13C618549870 Q30570683-E798C51A-AA20-4851-9CA8-76EB897D0FCC Q31170430-715998CC-93B3-46AE-9528-FD9DBE45F48F Q33285128-F06E8A41-9058-4C6B-9DA8-638261C47CB7 Q33570363-42064F78-6D94-4BFF-882B-2ACA0DAF9A4F Q33694588-5E36588A-A402-40DD-850F-CAA9FB340602 Q33734547-4C4B6BDA-1D27-4592-9371-4A2087D0AD8D Q33855252-E253837E-08B3-486C-974C-8F5C194F6867 Q33891014-57F65344-D1BD-473E-AC43-64ED6EFAA4CA Q33913618-88E76EE6-6415-47ED-A7F3-4C331A459BF5 Q34002166-C495029B-A1D2-4B58-9E94-67644AE4FDF5 Q34031196-30F8C225-2B04-4E1D-B97A-01EB5D3CCB66 Q34363640-C97C6E50-E0B0-48C7-AC61-C86764D2A111 Q34411429-556A13E9-53CC-4DDC-9A58-ABBF12A47EEB Q34412881-46E4A914-BD53-48CA-87EA-80C33ED851C9 Q34549351-8C1A2E09-141B-4456-A2CB-6BA0CA95C6AC Q34569730-C291439E-48DC-4325-A914-576777339DF9 Q34580378-C5BB9D03-1402-43F8-B202-91E64E599C3E Q34624399-D8EC7C04-2AA2-475C-89F3-A52E36FFA6D8 Q34685446-EFFCABAE-5BC5-4B91-84C4-D05E6447E6C5 Q34714911-CBEA0472-2103-407C-823C-B030291487FD Q34771899-373A37BD-A397-4B79-ACB4-EC4DA9C21591 Q34886367-98902F92-64F4-4D5A-A440-7B6FB7AB06F9 Q34947293-9DC45D55-4479-47E9-93CF-AB404846FC6C Q35036100-FAB0BC3A-5A74-4DFD-8946-401F83B78104

P2860

Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis.

http://www.wikidata.org/entity/Q36323476

description

2003 nî lūn-bûn

@nan

2003年の論文

@ja

2003年学术文章

@wuu

2003年学术文章

@zh-cn

2003年学术文章

@zh-hans

2003年学术文章

@zh-my

2003年学术文章

@zh-sg

2003年學術文章

@yue

2003年學術文章

@zh

2003年學術文章

@zh-hant

name

Proprotein convertase cleavage ...... nitiate melanosome biogenesis.

@ast

Proprotein convertase cleavage ...... nitiate melanosome biogenesis.

@en

type

label

Proprotein convertase cleavage ...... nitiate melanosome biogenesis.

@ast

Proprotein convertase cleavage ...... nitiate melanosome biogenesis.

@en

prefLabel

Proprotein convertase cleavage ...... nitiate melanosome biogenesis.

@ast

Proprotein convertase cleavage ...... nitiate melanosome biogenesis.

@en

P1433

Q36323476-B3A0DAF4-A79B-45EB-A895-7773993641E3

P1476

Q36323476-2A9DC6E5-19AE-46F2-BA21-C96A30B51174

P2093

Q36323476-1019327A-92A5-452C-86C8-437A56F47BEF

Q36323476-2784FE64-81A5-42A5-AEE5-C9CA869EEF31

Q36323476-4617AB37-8026-4634-B6E4-21746BF6C924

Q36323476-4D322B53-62C8-4D18-8DFC-ED53ACB65C50

Q36323476-DB656F04-3C7F-466C-B692-AE5855DB7B72

Q36323476-DEDCB180-5D6A-4E92-BCB7-3791D4A75BE2

P2860

Q36323476-0B04ED5E-4DEF-4A6C-9B0A-677E7D79F508

Q36323476-0C9DAABE-D5A5-4A49-8DB6-10E41CED66B8

Q36323476-1155461B-A9F0-435C-9AA1-0A3FB269EFF2

Q36323476-1407861F-4928-424C-BC5F-891BD1519E7F

Q36323476-1CA77048-9E99-458D-A92E-3D2DEA7B90C0

Q36323476-297980F7-AAB0-4715-BB90-195BF8006341

Q36323476-2BFD28E2-4AEE-42B8-8287-5966DF653BA3

Q36323476-33BD92F9-6390-4712-9590-5AA0130487FE

Q36323476-395AB270-E923-46A2-83D7-CC6A1E2F7005

Q36323476-396777E0-419C-4ADE-9D15-E1BDC03506A3

P304

Q36323476-0B835FAE-C5ED-434A-936B-0CE7B93BEE7E

P31

Q36323476-55655F03-D231-4E99-A9F0-95F6E7E89D4A

P356

Q36323476-990BFEE7-5656-4D58-B3AF-BF098F798C8F

P407

Q36323476-DC206794-9567-4B77-9CB3-521ACC693DAD

P433

Q36323476-ABF438C8-B25E-4332-93BC-AF880EBBD7BD

P478

Q36323476-E3A2791A-C2B9-45BD-A486-40DEADC2A696

P50

Q36323476-736AA43C-F7DA-435E-9B4D-4E549E91D733

P577

Q36323476-DDFD2917-D8B2-4D0D-92E6-28B2E1BF8B20

P5875

Q36323476-972C7FC7-61A9-40A7-B983-EE62959A1FB0

P698

Q36323476-AE8AB22B-A390-44E1-91B7-0E4CAA1BA5A2

P932

Q36323476-A3B265AC-9A88-4A38-923C-B6CC7FF37A52

P356

P1433

Journal of Cell Biology

P1476

Proprotein convertase cleavage ...... nitiate melanosome biogenesis.

@en

P2093

Alexander C Theos

http://www.w3.org/2001/XMLSchema#string

Danielle Tenza

http://www.w3.org/2001/XMLSchema#string

Dawn C Harper

http://www.w3.org/2001/XMLSchema#string

Graça Raposo

http://www.w3.org/2001/XMLSchema#string

Joanne F Berson

http://www.w3.org/2001/XMLSchema#string

Michael S Marks

http://www.w3.org/2001/XMLSchema#string

P2860

Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia

Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules

Pmel17 initiates premelanosome morphogenesis within multivesicular bodies

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation

A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

Isolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4+ T lymphocytes

Furin at the cutting edge: from protein traffic to embryogenesis and disease

Distinct protein sorting and localization to premelanosomes, melanosomes, and lysosomes in pigmented melanocytic cells

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

P304

521-533

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1083/JCB.200302072

http://www.w3.org/2001/XMLSchema#string

P407

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

161

http://www.w3.org/2001/XMLSchema#string

P50

P577

2003-05-05T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

10772142

http://www.w3.org/2001/XMLSchema#string

P698

12732614

http://www.w3.org/2001/XMLSchema#string

P932

2172928

http://www.w3.org/2001/XMLSchema#string