K-loop insertion restores microtubule depolymerizing activity of a "neckless" MCAK mutant
about
Regulation of localization and activity of the microtubule depolymerase MCAKMCAK associates with the tips of polymerizing microtubulesThe kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.Divergent microtubule assembly rates after short- versus long-term loss of end-modulating kinesins.The far C-terminus of MCAK regulates its conformation and spindle pole focusing.MCAK, a Kin I kinesin, increases the catastrophe frequency of steady-state HeLa cell microtubules in an ATP-dependent manner in vitroCik1 targets the minus-end kinesin depolymerase kar3 to microtubule plus ends.A kinesin-13 mutant catalytically depolymerizes microtubules in ADPCatalysis of the microtubule on-rate is the major parameter regulating the depolymerase activity of MCAK.Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPKα) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches.Aurora B inhibits MCAK activity through a phosphoconformational switch that reduces microtubule associationAtKinesin-13A is located on Golgi-associated vesicle and involved in vesicle formation/budding in Arabidopsis root-cap peripheral cellsMCAK-mediated regulation of endothelial cell microtubule dynamics is mechanosensitive to myosin-II contractility.Flagellar kinesins in protists.Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin.In vitro and in vivo analysis of microtubule-destabilizing kinesinsAurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E.Kinesins at a glanceMCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment.Full-length dimeric MCAK is a more efficient microtubule depolymerase than minimal domain monomeric MCAKXMAP215 polymerase activity is built by combining multiple tubulin-binding TOG domains and a basic lattice-binding region.Unconventional motoring: an overview of the Kin C and Kin I kinesins.Nucleotide exchange in dimeric MCAK induces longitudinal and lateral stress at microtubule ends to support depolymerization.The interplay of the N- and C-terminal domains of MCAK control microtubule depolymerization activity and spindle assembly.Differential interactions of the formins INF2, mDia1, and mDia2 with microtubules.Breathing down the neck of Unc104.Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.Cytoskeletal motors in Arabidopsis. Sixty-one kinesins and seventeen myosins.MCAK facilitates chromosome movement by promoting kinetochore microtubule turnoverRegulation of KinI kinesin ATPase activity by binding to the microtubule lattice.Visualisation of a kinesin-13 motor on microtubule end mimics.The diffusive interaction of microtubule binding proteins.A new model for binding of kinesin 13 to curved microtubule protofilamentsMotor domain phosphorylation and regulation of the Drosophila kinesin 13, KLP10A.Structure of a kinesin microtubule depolymerization machine.Kinesin-13s in mitosis: Key players in the spatial and temporal organization of spindle microtubules.The molecular basis for kinesin functional specificity during mitosis.Discovery of Thalicthuberine as a Novel Antimitotic Agent from Nature that Disrupts Microtubule Dynamics and Induces Apoptosis in Prostate Cancer Cells.Molecular insight into the regulation and function of MCAK.Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphase.
P2860
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P2860
K-loop insertion restores microtubule depolymerizing activity of a "neckless" MCAK mutant
description
2002 nî lūn-bûn
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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name
K-loop insertion restores microtubule depolymerizing activity of a "neckless" MCAK mutant
@ast
K-loop insertion restores microtubule depolymerizing activity of a "neckless" MCAK mutant
@en
type
label
K-loop insertion restores microtubule depolymerizing activity of a "neckless" MCAK mutant
@ast
K-loop insertion restores microtubule depolymerizing activity of a "neckless" MCAK mutant
@en
prefLabel
K-loop insertion restores microtubule depolymerizing activity of a "neckless" MCAK mutant
@ast
K-loop insertion restores microtubule depolymerizing activity of a "neckless" MCAK mutant
@en
P2093
P2860
P356
P1476
K-loop insertion restores microtubule depolymerizing activity of a "neckless" MCAK mutant
@en
P2093
Linda Wordeman
Michael Wagenbach
Yulia Ovechkina
P2860
P304
P356
10.1083/JCB.200205089
P407
P577
2002-11-01T00:00:00Z