Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin
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The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAKThe far C-terminus of MCAK regulates its conformation and spindle pole focusing.Recruitment of EB1, a master regulator of microtubule dynamics, to the surface of the Theileria annulata schizontStructure of the Kinesin13-Microtubule Ring ComplexYeast kinesin-8 depolymerizes microtubules in a length-dependent manner.MCAK, a Kin I kinesin, increases the catastrophe frequency of steady-state HeLa cell microtubules in an ATP-dependent manner in vitroThe influence of chromosome flexibility on chromosome transport during anaphase A.Deciphering protein function during mitosis in PtK cells using RNAi.Kinesin-13s form rings around microtubulesA kinesin-13 mutant catalytically depolymerizes microtubules in ADPCatalysis of the microtubule on-rate is the major parameter regulating the depolymerase activity of MCAK.Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPKα) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches.Aurora B inhibits MCAK activity through a phosphoconformational switch that reduces microtubule associationOsKinesin-13A is an active microtubule depolymerase involved in glume length regulation via affecting cell elongation.Aurora A orchestrates entosis by regulating a dynamic MCAK-TIP150 interactionFlagellar kinesins in protists.Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin.The microtubule-destabilizing kinesin XKCM1 regulates microtubule dynamic instability in cells.Control of MCAK degradation and removal from centromeresMCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment.Full-length dimeric MCAK is a more efficient microtubule depolymerase than minimal domain monomeric MCAKPLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activityUnconventional motoring: an overview of the Kin C and Kin I kinesins.Nucleotide exchange in dimeric MCAK induces longitudinal and lateral stress at microtubule ends to support depolymerization.The interplay of the N- and C-terminal domains of MCAK control microtubule depolymerization activity and spindle assembly.Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.Building the Microtubule Cytoskeleton Piece by PieceNew Insights into the Coupling between Microtubule Depolymerization and ATP Hydrolysis by Kinesin-13 Protein Kif2C.MCAK facilitates chromosome movement by promoting kinetochore microtubule turnoverIdentification of XMAP215 as a microtubule-destabilizing factor in Xenopus egg extract by biochemical purification.K-loop insertion restores microtubule depolymerizing activity of a "neckless" MCAK mutantRegulation of KinI kinesin ATPase activity by binding to the microtubule lattice.Kinesin-13 and tubulin posttranslational modifications regulate microtubule growth in axon regenerationSignaling-dependent phosphorylation of mitotic centromere-associated kinesin regulates microtubule depolymerization and its centrosomal localizationEpothilones in the treatment of cancer.Cytoskeletal transport in the aging brain: focus on the cholinergic system.Distinct Interaction Modes of the Kinesin-13 Motor Domain with the Microtubule.Rings, bracelets, sleeves, and chevrons: new structures of kinetochore proteinsMCAK and paclitaxel have differential effects on spindle microtubule organization and dynamics.Cell cycle dependent degradation of MCAK: evidence against a role in anaphase chromosome movement
P2860
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P2860
Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesin
description
2001 nî lūn-bûn
@nan
2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Molecular dissection of the mi ...... centromere-associated kinesin
@ast
Molecular dissection of the mi ...... centromere-associated kinesin
@en
Molecular dissection of the mi ...... centromere-associated kinesin
@nl
type
label
Molecular dissection of the mi ...... centromere-associated kinesin
@ast
Molecular dissection of the mi ...... centromere-associated kinesin
@en
Molecular dissection of the mi ...... centromere-associated kinesin
@nl
prefLabel
Molecular dissection of the mi ...... centromere-associated kinesin
@ast
Molecular dissection of the mi ...... centromere-associated kinesin
@en
Molecular dissection of the mi ...... centromere-associated kinesin
@nl
P2093
P2860
P356
P1476
Molecular dissection of the mi ...... centromere-associated kinesin
@en
P2093
P2860
P304
P356
10.1074/JBC.M106626200
P407
P577
2001-09-14T00:00:00Z