The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells
about
The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signalingModeling the study of DNA damage responses in miceFunctional genomics lead to new therapies in follicular lymphomaKATs in cancer: functions and therapiesHow animal models of leukaemias have already benefited patientsMicroRNA-regulated pathways in hematological malignancies: how to avoid cells playing out of tuneAnimal models of leukemia: any closer to the real thing?Man's best friend: what can pet dogs teach us about non-Hodgkin's lymphoma?A role for E2F activities in determining the fate of Myc-induced lymphomagenesisZebrafish Models of Human Leukemia: Technological Advances and Mechanistic InsightsBET bromodomain inhibition as a therapeutic strategy to target c-MycTransgenic models of lymphoid neoplasia and development of a pan-hematopoietic vectorApoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesisInhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumorsMolecular mechanisms of cancer.The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imagingN-myc transgene promotes B lymphoid proliferation, elicits lymphomas and reveals cross-regulation with c-myc.IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expressionMurine models of acute leukemia: important tools in current pediatric leukemia research.Tumor-specific and proliferation-specific gene expression typifies murine transgenic B cell lymphomagenesis.Genetic Modeling of PIM Proteins in Cancer: Proviral Tagging and Cooperation with Oncogenes, Tumor Suppressor Genes, and Carcinogens.E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia.DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene.Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease.Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expressionIncreased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation.Sept4/ARTS is required for stem cell apoptosis and tumor suppression.Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model.RAE1 ligands for the NKG2D receptor are regulated by STING-dependent DNA sensor pathways in lymphomaMaximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also BimCSN6 drives carcinogenesis by positively regulating Myc stability.Dominant negative retinoic acid receptor initiates tumor formation in mice.Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatallyUtilization of the Eμ-Myc mouse to model heterogeneity of therapeutic response.ATM-dependent spontaneous regression of early Eμ-myc-induced murine B-cell leukemia depends on natural killer and T cellsCD19 CAR-targeted T cells induce long-term remission and B Cell Aplasia in an immunocompetent mouse model of B cell acute lymphoblastic leukemia.Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia.Apoptosis is the essential target of selective pressure against p53, whereas loss of additional p53 functions facilitates carcinoma progression.A rationally designed nanoparticle for RNA interference therapy in B-lineage lymphoid malignancies
P2860
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P2860
The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年学术文章
@wuu
1988年学术文章
@zh-cn
1988年学术文章
@zh-hans
1988年学术文章
@zh-my
1988年学术文章
@zh-sg
1988年學術文章
@yue
1988年學術文章
@zh
1988年學術文章
@zh-hant
name
The E mu-myc transgenic mouse. ...... and leukemia of early B cells
@ast
The E mu-myc transgenic mouse. ...... and leukemia of early B cells
@en
type
label
The E mu-myc transgenic mouse. ...... and leukemia of early B cells
@ast
The E mu-myc transgenic mouse. ...... and leukemia of early B cells
@en
prefLabel
The E mu-myc transgenic mouse. ...... and leukemia of early B cells
@ast
The E mu-myc transgenic mouse. ...... and leukemia of early B cells
@en
P2093
P2860
P356
P1476
The E mu-myc transgenic mouse. ...... and leukemia of early B cells
@en
P2093
A W Harris
C A Pinkert
M Crawford
R L Brinster
W Y Langdon
P2860
P304
P356
10.1084/JEM.167.2.353
P407
P577
1988-02-01T00:00:00Z