Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules
about
Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transductionThymus, innate immunity and autoimmune arthritis: interplay of gene and environmentMitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient miceNck adapter proteins: functional versatility in T cellsSignalling scaffolds and adaptors in T-cell immunity.A new function for LAT and CD8 during CD8-mediated apoptosis that is independent of TCR signal transductionLineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4+CD8+ thymocytes into mature T cellsInduction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation.Development and function of T cells in T cell antigen receptor/CD3 zeta knockout mice reconstituted with Fc epsilon RI gamma.CD4-CD8 lineage commitment: an inside view.ZAP-70 protein tyrosine kinase is constitutively targeted to the T cell cortex independently of its SH2 domainsDevelopmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes.Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function.Nuclear factors that mediate intrathymic signals are developmentally regulated.Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytesThe cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.Partial signaling by CD8+ T cells in response to antagonist ligands.Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selectionZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs (ITAMs) in immature CD4(+)8(+) thymocytes with limiting p56(lck).Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cells.Receptor avidity and costimulation specify the intracellular Ca2+ signaling pattern in CD4(+)CD8(+) thymocytes.Antagonist peptide selects thymocytes expressing a class II major histocompatibility complex-restricted T cell receptor into the CD8 lineageAn antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4Disruption of the CD4-major histocompatibility complex class II interaction blocks the development of CD4(+) T cells in vivoLigation of CD8 leads to apoptosis of thymocytes that have not undergone positive selection.What Happens in the Thymus Does Not Stay in the Thymus: How T Cells Recycle the CD4+-CD8+ Lineage Commitment Transcriptional Circuitry To Control Their Function.Homodimerization and heterodimerization of minimal zinc(II)-binding-domain peptides of T-cell proteins CD4, CD8alpha, and Lck.Transient alteration of T cell fine specificity by a strong primary stimulus correlates with T cell receptor down-regulation.CD8 lineage commitment in the absence of CD8.The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 complexes.ZAP-70: an essential kinase in T-cell signalingStrict Major Histocompatibility Complex Molecule Class-Specific Binding by Co-Receptors Enforces MHC-Restricted αβ TCR Recognition during T Lineage Subset CommitmentCodification of bidentate pMHC interaction with TCR and its co-receptor.Thymocyte selection in Vav and IRF-1 gene-deficient mice.CD3ζ-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy.Molecular and genetic insights into T-cell antigen receptor signaling.Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance.Contributions of the T cell receptor-associated CD3gamma-ITAM to thymocyte selectionLAPTM5 promotes lysosomal degradation of intracellular CD3ζ but not of cell surface CD3ζ.
P2860
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P2860
Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Regulation of T cell receptor ...... sing both coreceptor molecules
@ast
Regulation of T cell receptor ...... sing both coreceptor molecules
@en
type
label
Regulation of T cell receptor ...... sing both coreceptor molecules
@ast
Regulation of T cell receptor ...... sing both coreceptor molecules
@en
prefLabel
Regulation of T cell receptor ...... sing both coreceptor molecules
@ast
Regulation of T cell receptor ...... sing both coreceptor molecules
@en
P2093
P2860
P356
P1476
Regulation of T cell receptor ...... sing both coreceptor molecules
@en
P2093
J Jefferson
L E Samelson
L H Glimcher
R D Klausner
P2860
P304
P356
10.1084/JEM.178.5.1701
P407
P577
1993-11-01T00:00:00Z