The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.
about
Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signalingThemis, a T cell-specific protein important for late thymocyte developmentTOX provides a link between calcineurin activation and CD8 lineage commitmentDistinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cellsItk derived signals regulate the expression of Th-POK and controls the development of CD4 T cells.TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo.Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.Effects of complementarity determining region mutations on the affinity of an alpha/beta T cell receptor: measuring the energy associated with CD4/CD8 repertoire skewingLineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cells.Role of 2CT cell receptor residues in the binding of self- and allo-major histocompatibility complexesAutonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk).The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymusUnraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cellsThymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47Lineage commitment in the thymus: only the most differentiated (TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis.Commitment of immature CD4+8+ thymocytes to the CD4 lineage requires CD3 signaling but does not require expression of clonotypic T cell receptor (TCR) chainsRole of the transcription factor Th-POK in CD4:CD8 lineage commitment.Commitment issues: linking positive selection signals and lineage diversification in the thymus.TCR and Notch signaling in CD4 and CD8 T-cell development.The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells.Dynamic repositioning of CD4 and CD8 genes during T cell development.CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity.Antagonist peptide selects thymocytes expressing a class II major histocompatibility complex-restricted T cell receptor into the CD8 lineageAn antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands.Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice.Cutting Edge: Ikaros null thymocytes mature into the CD4 lineage with reduced TCR signal: A study using CD3{zeta} immunoreceptor tyrosine-based activation motif transgenic mice.Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes.CD8 lineage commitment in the absence of CD8.Correlating notch signaling with thymocyte maturation.Strict Major Histocompatibility Complex Molecule Class-Specific Binding by Co-Receptors Enforces MHC-Restricted αβ TCR Recognition during T Lineage Subset CommitmentCodification of bidentate pMHC interaction with TCR and its co-receptor.CD4/CD8 lineage commitment: back to instruction?Asynchronous coreceptor downregulation after positive thymic selection: prolonged maintenance of the double positive state in CD8 lineage differentiation due to sustained biosynthesis of the CD4 coreceptor.Lipid-mediated presentation of MHC class II molecules guides thymocytes to the CD4 lineage.T-cell fate.Suppressor of cytokine signaling 1 is required for the differentiation of CD4+ T cells.The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment.CD4/CD8 lineage commitment: matching fate with competence.Molecular requirements for lineage commitment in the thymus--antibody-mediated receptor engagements reveal a central role for lck in lineage decisions.
P2860
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P2860
The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.
@ast
The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.
@en
type
label
The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.
@ast
The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.
@en
prefLabel
The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.
@ast
The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.
@en
P2093
P2860
P356
P1476
The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.
@en
P2093
P2860
P304
P356
10.1084/JEM.183.3.731
P407
P577
1996-03-01T00:00:00Z