The intracellular signal transduction mechanism of interleukin 5 in eosinophils: the involvement of lyn tyrosine kinase and the Ras-Raf-1-MEK-microtubule-associated protein kinase pathway
about
Lyn is involved in CD24-induced ERK1/2 activation in colorectal cancerInterleukin-6, CD45 and the src-kinases in myeloma cell proliferationIdentification of UNC119 as a novel activator of SRC-type tyrosine kinasesApplication of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemiaInterleukin-5 and IL-5 receptor in health and diseasesEngagement of the CrkL adapter in interleukin-5 signaling in eosinophils.Binding of src-like kinases to the beta-subunit of the interleukin-3 receptor.Advances in the immunobiology of eosinophils and their role in disease.New aspects of degranulation and fates of airway mucosal eosinophils.Controlling allergic inflammation by signaling regulation of eosinophils.Identification of pro-inflammatory cytokines associated with muscle invasive bladder cancer; the roles of IL-5, IL-20, and IL-28A.Interleukin-5: a novel target for asthma therapy.Regulation of eosinophil viability by cytokines.Intracellular signal transduction in eosinophils and its clinical significance.Mitogen-activated protein kinase signalling and ERK1/2 bistability in asthma.Balanced interactions between Lyn, the p85alpha regulatory subunit of class I(A) phosphatidylinositol-3-kinase, and SHIP are essential for mast cell growth and maturation.Biochemical assessment of intracellular signal transduction pathways in eosinophils: implications for pharmacotherapy.Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival.Lyn, Jak2, and Raf-1 kinases are critical for the antiapoptotic effect of interleukin 5, whereas only Raf-1 kinase is essential for eosinophil activation and degranulation.Mechanisms of acute eosinophil mobilization from the bone marrow stimulated by interleukin 5: the role of specific adhesion molecules and phosphatidylinositol 3-kinaseA critical role of Lyn and Fyn for B cell responses to CD38 ligation and interleukin 5A functional bipartite nuclear localisation signal in the cytokine interleukin-5.Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2.trans-Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulationIn vitro effects of budesonide on eosinophil-basophil lineage commitment.The signaling mechanism of eosinophil activation.Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor.Regulation of spontaneous eosinophil apoptosis-a neglected area of importance.Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness.Chemoattractant-induced signaling via the Ras-ERK and PI3K-Akt networks, along with leukotriene C4 release, is dependent on the tyrosine kinase Lyn in IL-5- and IL-3-primed human blood eosinophils.Opposing effects of sodium salicylate and haematopoietic cytokines IL-3, IL-5 and GM-CSF on mitogen-activated protein kinases and apoptosis of EoL-1 cells.Sequences within fibrinogen and intercellular adhesion molecule-1 (ICAM-1) modulate signals required for mitogenesis.Requirement of Src kinase Lyn for induction of DNA synthesis by granulocyte colony-stimulating factor.Autocrine activation of the IL-3/GM-CSF/IL-5 signaling pathway in leukemic cells.Multiple tyrosine residues in the intracellular domain of the common beta subunit of the interleukin 5 receptor are involved in activation of STAT5.The cytokine interleukin-5 (IL-5) effects cotransport of its receptor subunits to the nucleus in vitro.Eosinophils in allergic diseases: immunopharmacological regulation.Biological and molecular characteristics of interleukin-5 and its receptor.Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils.The mechanisms of serum-treated zymosan (STZ)-induced oxidative metabolism by human eosinophils and the effects of IL-5 priming.
P2860
Q24338897-5273A1F9-9309-4094-A5C3-D55F1BFD1854Q28210841-0637BB29-EC75-4CFE-B23E-F3E01784F87EQ28218689-37552786-5C1E-4FA7-B85E-B2CE68805AABQ28534259-B480D5B6-2DBE-406A-AD97-AD178F8C31BEQ28730921-AFA3805A-1CCC-4AC2-9F07-4DE6A75BB92AQ30168855-09B6C298-FAD8-47A9-843F-3B8E997985E8Q30176500-09C1BA62-3782-4ED9-BB1C-477394EA13ABQ33773048-D79723A9-B849-4102-8C32-92B7CDE5A1F3Q33942417-C2644D84-4965-41E2-A7D4-DB2AE28AA359Q34184626-88D1A232-5899-4258-9519-5CBB2A1404ACQ34409699-D6027CE1-352D-43BE-ACB4-4447A0B575A0Q34451982-BF388416-78E8-4B88-9AA4-A3DDC22AE418Q34580000-8ACD5A1C-3ADC-43C8-ADBD-182AB1E830E5Q34687385-952CC70B-9E86-42A9-B1F1-8DF7643EBF05Q35047271-6E83B560-1E80-4E15-8C21-307E0A686EBEQ35274032-66806847-FD34-4934-8C7B-21D1E641387CQ35743287-7C95BF89-EC5B-4315-B987-2757F8C6CFF9Q36380535-D4AD8B24-7C72-4E1A-AC74-2726735A1B95Q36401490-7F31CD26-C9C2-4F97-854B-FA80813FAB9FQ36401641-08AF0475-7A68-4C84-AFA2-574228DD11A5Q36585953-0527FD29-9A79-4F51-AA44-EBE01902508DQ36858506-667C546C-828C-4ED5-8AE1-8D3FD9FE3909Q36866432-74830FCC-7C61-4A62-8D07-35AEBC1692B5Q37002367-A7ACF1A6-7C5A-46AE-B516-C7596B4F37E4Q37022427-28C14AA8-DEA5-4C8B-B64A-6BCFAC734F99Q37754560-0940CDE4-1A3C-4665-B39E-3AF08D3E63D8Q37957225-BBBCED7F-2A69-481B-B549-A9889039F9BEQ38256352-4E7F0C17-F1ED-4450-BA37-ACB9EA93C2F9Q38515481-09BB34DC-FDEB-4A3F-830E-F7D67090E589Q39627809-FE44716A-5E54-4677-9C27-18A32A6072DCQ40915989-972D73C6-0E82-4BB0-9C83-9DB4F6CFF65EQ40960167-89FCD31C-EB98-42EE-91B9-AB7DBE4BC904Q41062090-6D43E769-46C8-45B9-8CB5-6244B945B194Q41085650-23B485A1-3009-46CD-9C34-F7BC758753F6Q41098824-7B42A6CB-F11F-402A-BD7C-0F8484FD0996Q41103584-307FECE6-9E98-4A75-9713-BC41B7E60A93Q41685532-693F5BE9-1557-498A-B210-50AF85F83DC8Q41722186-2473E3EF-6887-4E33-8C1B-953A3EF3EC90Q42943439-3C259F58-EB09-442D-BF0E-EE1BDCE0BE6FQ43650427-D559B45D-B438-49BE-BB7F-FEEB1B4E4DC7
P2860
The intracellular signal transduction mechanism of interleukin 5 in eosinophils: the involvement of lyn tyrosine kinase and the Ras-Raf-1-MEK-microtubule-associated protein kinase pathway
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
The intracellular signal trans ...... ociated protein kinase pathway
@ast
The intracellular signal trans ...... ociated protein kinase pathway
@en
type
label
The intracellular signal trans ...... ociated protein kinase pathway
@ast
The intracellular signal trans ...... ociated protein kinase pathway
@en
prefLabel
The intracellular signal trans ...... ociated protein kinase pathway
@ast
The intracellular signal trans ...... ociated protein kinase pathway
@en
P2093
P2860
P356
P1476
The intracellular signal trans ...... ociated protein kinase pathway
@en
P2093
P2860
P304
P356
10.1084/JEM.181.5.1827
P407
P577
1995-05-01T00:00:00Z