Activation of Raf as a result of recruitment to the plasma membrane
about
KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activationCdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylationImpaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signalingThe RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membraneDirect activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivativeRegulation of Raf-1 kinase activity by the 14-3-3 family of proteinsRole of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent mannerBinding of c-Raf1 kinase to a conserved acidic sequence within the carboxyl-terminal region of the HIV-1 Nef proteinMitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptorCloning and characterization of p97MAPK, a novel human homolog of rat ERK-3Spatial regulation of Raf kinase signaling by RKTGThe RafC1 cysteine-rich domain contains multiple distinct regulatory epitopes which control Ras-dependent Raf activationThe MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3Translocation of ornithine decarboxylase to the surface membrane during cell activation and transformationSerine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activationRas binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase.Association of yeast adenylyl cyclase with cyclase-associated protein CAP forms a second Ras-binding site which mediates its Ras-dependent activationThe strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPasesActivation of phosphoinositide 3-kinase by interaction with Ras and by point mutationRas membrane targeting is essential for glucose signaling but not for viability in yeastIdentification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and RapA novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathwaysTranslocation of PKN from the cytosol to the nucleus induced by stressesIn its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinaseRAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2.Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding sitePhosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signalingInteraction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cellsRheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals.A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK functionA human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase familyGrowth-inhibitory activity and downregulation of the class II tumor-suppressor gene H-rev107 in tumor cell lines and experimental tumorsRab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by rasRaf activation is regulated by tyrosine 510 phosphorylation in DrosophilaA downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae.Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast.Dual prenylation is required for Rab protein localization and function
P2860
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P2860
Activation of Raf as a result of recruitment to the plasma membrane
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Activation of Raf as a result of recruitment to the plasma membrane
@ast
Activation of Raf as a result of recruitment to the plasma membrane
@en
type
label
Activation of Raf as a result of recruitment to the plasma membrane
@ast
Activation of Raf as a result of recruitment to the plasma membrane
@en
prefLabel
Activation of Raf as a result of recruitment to the plasma membrane
@ast
Activation of Raf as a result of recruitment to the plasma membrane
@en
P2093
P3181
P356
P1433
P1476
Activation of Raf as a result of recruitment to the plasma membrane
@en
P2093
Cadwallader K
Hancock JF
Macdonald SG
P304
P3181
P356
10.1126/SCIENCE.7811320
P407
P577
1994-06-03T00:00:00Z