Lineage commitment in the thymus: only the most differentiated (TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis.
about
ITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytesCD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic developmentHeightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes.Essential role of PI3Kdelta and PI3Kgamma in thymocyte survival.Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection.Commitment of immature CD4+8+ thymocytes to the CD4 lineage requires CD3 signaling but does not require expression of clonotypic T cell receptor (TCR) chainsVisualization of CD4/CD8 T cell commitment.CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity.The action of Bax and bcl-2 on T cell selectionGads-deficient thymocytes are blocked at the transitional single positive CD4+ stage.Differential susceptibility and maturation of thymocyte subsets during Salmonella Typhimurium infection: insights on the roles of glucocorticoids and Interferon-gammaCD4/CD8 lineage commitment: matching fate with competence.
P2860
Q24671904-5913D18D-AF86-433F-9840-D3397D56419DQ33832059-68157733-0A55-44BD-A2EF-0EA7DCA5F1DCQ34059078-20EB344A-153A-4880-9680-C13A33306C1BQ35849523-2CA72C66-5B88-4324-93D9-E95E27CE0D27Q36370544-EE63C7EE-BE40-4DBA-8B73-8D0FAE81B7A3Q36380314-B19999ED-8CE4-4BBA-BE4B-BDBA79EDD2BBQ36401327-36155D63-A216-4F55-96EF-F7820926293FQ36401360-CF158DBF-1AF0-45B6-A937-4E800F449F06Q36401807-2ED065E7-843C-42D9-8663-B69677745149Q37400400-15FE8B56-AE98-4449-AE92-21CA4140CF05Q37587752-6CCC58D2-7039-4B2F-96CA-B99FF004325AQ51093044-55606CEF-8129-4DAB-A030-BBF20E1DE44C
P2860
Lineage commitment in the thymus: only the most differentiated (TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Lineage commitment in the thym ...... rminated CD4 or CD8 synthesis.
@ast
Lineage commitment in the thym ...... rminated CD4 or CD8 synthesis.
@en
type
label
Lineage commitment in the thym ...... rminated CD4 or CD8 synthesis.
@ast
Lineage commitment in the thym ...... rminated CD4 or CD8 synthesis.
@en
prefLabel
Lineage commitment in the thym ...... rminated CD4 or CD8 synthesis.
@ast
Lineage commitment in the thym ...... rminated CD4 or CD8 synthesis.
@en
P2093
P2860
P356
P1476
Lineage commitment in the thym ...... rminated CD4 or CD8 synthesis.
@en
P2093
P2860
P304
P356
10.1084/JEM.184.6.2091
P407
P577
1996-12-01T00:00:00Z