TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.
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The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.TREM2 in Neurodegenerative Diseases.TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy.Microglia express ABI3 in the brains of Alzheimer's disease and Nasu-Hakola disease.Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system.The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.TREM2 expression in the human brain: a marker of monocyte recruitment?Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease.Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2).TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.Alzheimer's Disease, Oligomers, and Inflammation.Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia.The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.Microglia in Alzheimer's diseaseCerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroupHuman Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in PhagocytosisWhite matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's diseaseInflammation: the link between comorbidities, genetics, and Alzheimer's diseaseThe Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humansMicroglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases
P2860
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P2860
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.
description
2017 nî lūn-bûn
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2017年の論文
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2017年学术文章
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2017年学术文章
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2017年学术文章
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2017年学术文章
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2017年学术文章
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2017年學術文章
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2017年學術文章
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name
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.
@ast
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.
@en
type
label
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.
@ast
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.
@en
prefLabel
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.
@ast
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.
@en
P2093
P2860
P50
P921
P356
P1433
P1476
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury
@en
P2093
Anja Capell
Anna Daria
Bettina Brunner
Charlotte Madore
Dietrich Trümbach
Georg Werner
Martin Kerschensteiner
Nicolas Snaidero
Oleg Butovsky
Sebastian Bultmann
P2860
P304
P356
10.15252/EMBR.201743922
P577
2017-05-08T00:00:00Z