Selective activation of the calcium signaling pathway by altered peptide ligands
about
Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor.High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics.Mathematical modeling of chimeric TCR triggering predicts the magnitude of target lysis and its impairment by TCR downmodulationZap-70-independent Ca(2+) mobilization and Erk activation in Jurkat T cells in response to T-cell antigen receptor ligation.Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity.Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance.Systemic immunomodulation of autoimmune disease using MHC-derived recombinant TCR ligandsChronic tumor necrosis factor alters T cell responses by attenuating T cell receptor signaling.Kinetics and extent of T cell activation as measured with the calcium signalDissociation of intracellular signaling pathways in response to partial agonist ligands of the T cell receptor.Cyclin-dependent kinases: molecular switches controlling anergy and potential therapeutic targets for tolerance.Natural killer T-cell autoreactivity leads to a specialized activation stateSignaling defects in anti-tumor T cellsAML1/Runx1 recruits calcineurin to regulate granulocyte macrophage colony-stimulating factor by Ets1 activation.Calcium regulation of GM-CSF by calmodulin-dependent kinase II phosphorylation of Ets1Heat-shock of normal t-cells and T-cell lines downregulates the TCR/CD3-mediated cytoplasmic Ca2+ responses and the production of inositol trisphosphate.T cell receptor (TCR) antagonism without a negative signal: evidence from T cell hybridomas expressing two independent TCRs.Carcinogen-modified dendritic cells induce immunosuppression by incomplete T-cell activation resulting from impaired antigen uptake and reduced CD86 expressionCD4 T cells in protection from influenza virus: Viral antigen specificity and functional potential
P2860
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P2860
Selective activation of the calcium signaling pathway by altered peptide ligands
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Selective activation of the calcium signaling pathway by altered peptide ligands
@ast
Selective activation of the calcium signaling pathway by altered peptide ligands
@en
type
label
Selective activation of the calcium signaling pathway by altered peptide ligands
@ast
Selective activation of the calcium signaling pathway by altered peptide ligands
@en
prefLabel
Selective activation of the calcium signaling pathway by altered peptide ligands
@ast
Selective activation of the calcium signaling pathway by altered peptide ligands
@en
P2093
P2860
P356
P1476
Selective activation of the calcium signaling pathway by altered peptide ligands
@en
P2093
Sloan-Lancaster J
Steinberg TH
P2860
P304
P356
10.1084/JEM.184.4.1525
P407
P577
1996-10-01T00:00:00Z