Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein.
about
SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processesMacrophage derived cystatin B/cathepsin B in HIV replication and neuropathogenesisBrain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeuticInflammasomes as therapeutic targets for Alzheimer's disease.Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaquesInteracting partners of macrophage-secreted cathepsin B contribute to HIV-induced neuronal apoptosis.Expression, purification, and characterization of human cystatin C monomers and oligomers.Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease.Autophagic/lysosomal dysfunction in Alzheimer's disease.Deciphering the molecular profile of plaques, memory decline and neuron loss in two mouse models for Alzheimer's disease by deep sequencing.Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease.Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer's disease.On the Run for Hippocampal Plasticity.Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors.Cross-interactions between the Alzheimer Disease Amyloid-β Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis.One protein, multiple pathologies: multifaceted involvement of amyloid β in neurodegenerative disorders of the brain and retina.Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?Clearance of cerebral Aβ in Alzheimer's disease: reassessing the role of microglia and monocytes.Microwave & magnetic proteomics of macrophages from patients with HIV-associated cognitive impairment.Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer's Disease.Aβ42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk between protein clearance pathways.Cysteine cathepsin activity regulation by glycosaminoglycans.A mechanistic model to predict effects of cathepsin B and cystatin C on β-amyloid aggregation and degradation.Cystatin C is differentially involved in multiple system atrophy phenotypes.Insights into the mechanism of cystatin C oligomer and amyloid formation and its interaction with β-amyloid.Potential Alzheimer's Disease Therapeutics Among Weak Cysteine Protease Inhibitors Exhibit Mechanistic Differences Regarding Extent of Cathepsin B Up-Regulation and Ability to Block Calpain.
P2860
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P2860
Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Cathepsin B degrades amyloid-β ...... man amyloid precursor protein.
@ast
Cathepsin B degrades amyloid-β ...... man amyloid precursor protein.
@en
type
label
Cathepsin B degrades amyloid-β ...... man amyloid precursor protein.
@ast
Cathepsin B degrades amyloid-β ...... man amyloid precursor protein.
@en
prefLabel
Cathepsin B degrades amyloid-β ...... man amyloid precursor protein.
@ast
Cathepsin B degrades amyloid-β ...... man amyloid precursor protein.
@en
P2093
P2860
P356
P1476
Cathepsin B degrades amyloid-β ...... man amyloid precursor protein.
@en
P2093
Anders Grubb
Binggui Sun
Yungui Zhou
P2860
P304
39834-39841
P356
10.1074/JBC.M112.371641
P407
P577
2012-09-28T00:00:00Z