Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach. - Wikidata - awgldk - TriplyDB

Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach.

Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach.

http://www.wikidata.org/entity/Q31023855

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Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides.Nitrated alpha-synuclein and microglial neuroregulatory activities.Microglia activation and anti-inflammatory regulation in Alzheimer's disease Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways.Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis.Cocaine potentiates cathepsin B secretion and neuronal apoptosis from HIV-infected macrophages.Toll-like receptor 4 promotes α-synuclein clearance and survival of nigral dopaminergic neurons.Proteolytic mechanisms in necrotic cell death and neurodegeneration.HIV-infected microglia mediate cathepsin B-induced neurotoxicity.Intraperitoneal injection of a hairpin RNA-expressing plasmid targeting urokinase-type plasminogen activator (uPA) receptor and uPA retards angiogenesis and inhibits intracranial tumor growth in nude mice.Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study.Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein.Improvement in recovery after experimental intracerebral hemorrhage using a selective cathepsin B and L inhibitor Anti-inflammatory and immune therapy for Alzheimer's disease: current status and future directions.Cudrania cochinchinensis attenuates amyloid β protein-mediated microglial activation and promotes glia-related clearance of amyloid β protein.Nitrated {alpha}-synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets Genomic profiles of damage and protection in human intracerebral hemorrhage.Proteomic studies of nitrated alpha-synuclein microglia regulation by CD4+CD25+ T cells.Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: a potential mechanism leading to chronic inflammation.Aspects of beta-amyloid as a biomarker for Alzheimer's disease.Kynurenines, neurodegeneration and Alzheimer's disease.Genomics and proteomics are changing discovery, development and clinical use of dementia drugs.Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease.Aβ degradation or cerebral perfusion? Divergent effects of multifunctional enzymes.HIV-1 Tat Promotes Lysosomal Exocytosis in Astrocytes and Contributes to Astrocyte-mediated Tat Neurotoxicity 14-3-3ε marks the amyloid-stimulated microglia long-term activation.Activity-Dependent Exocytosis of Lysosomes Regulates the Structural Plasticity of Dendritic Spines.Aβ degradation-the inside story.Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis.Death-associated protein kinase is activated by dephosphorylation in response to cerebral ischemia.Sensitization of stefin B-deficient thymocytes towards staurosporin-induced apoptosis is independent of cysteine cathepsins.Neurotoxicity of microglial cathepsin D revealed by secretome analysis.A mechanistic model to predict effects of cathepsin B and cystatin C on β-amyloid aggregation and degradation.

P2860

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P2860

Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach.

http://www.wikidata.org/entity/Q31023855

description

2003 nî lūn-bûn

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2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2003年の論文

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Identification of cathepsin B ...... functional genomics approach.

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Identification of cathepsin B ...... functional genomics approach.

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Identification of cathepsin B ...... functional genomics approach.

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Identification of cathepsin B ...... functional genomics approach.

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Identification of cathepsin B ...... functional genomics approach.

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Identification of cathepsin B ...... functional genomics approach.

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Identification of cathepsin B ...... functional genomics approach.

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P2093

Alan Chu

http://www.w3.org/2001/XMLSchema#string

Daniel Chin

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David von Schack

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Joseph Murray

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Karoly Nikolich

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Kristin Anton

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Laszlo Patthy

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Li Gan

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Mirella Gonzalez-Zulueta

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Roman Urfer

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P2860

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Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

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279

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14612454

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