The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues.
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Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activitiesICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cellsEnhanced etoposide sensitivity following adenovirus-mediated human topoisomerase IIalpha gene transfer is independent of topoisomerase IIbetaTopoisomerase II-mediated DNA damage is differently repaired during the cell cycle by non-homologous end joining and homologous recombinationImmunohistochemical analyses of DNA topoisomerase II isoforms in developing rat cerebellumDNA topoisomerase II distribution in mouse preimplantation embryosCasein kinase II catalyzes a mitotic phosphorylation on threonine 1342 of human DNA topoisomerase IIalpha, which is recognized by the 3F3/2 phosphoepitope antibody.Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II.Influence of cell cycle and oncogene activity upon topoisomerase IIalpha expression and drug toxicity.Simultaneous quantitation of topoisomerase II alpha and beta isoform mRNAs in lung tumor cells and normal and malignant lung tissue.Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor.Synthesis and evaluation of (18)F-labeled ATP competitive inhibitors of topoisomerase II as probes for imaging topoisomerase II expression.Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state.Topoisomerase II alpha gene amplification is a favorable prognostic factor in patients with HER2-positive metastatic breast cancer treated with trastuzumab.DNA topoisomerase IIalpha and -beta expression in human ovarian cancerTyrosine 656 in topoisomerase IIβ is important for the catalytic activity of the enzyme: Identification based on artifactual +80-Da modification at this siteThe significance of Epstein Barr virus (EBV) & DNA topoisomerase II alpha (DNA-Topo II alpha) immunoreactivity in normal oral mucosa, oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC).Concurrent inhibition of enzymatic activity and NF-Y-mediated transcription of Topoisomerase-IIα by bis-DemethoxyCurcumin in cancer cells.Topoisomerase II: a fitted mechanism for the chromatin landscape.Quantum dot-based immunofluorescent imaging and quantitative detection of TOP2A and prognostic value in triple-negative breast cancer.Topoisomerase 2 alpha: a real predictor of anthracycline efficacy?Role of topoisomerase IIbeta in the expression of developmentally regulated genes.DNA topoisomerase IIalpha expression correlates with cell proliferation but not with recurrence in intracranial meningiomas.Specificity protein 1 regulates topoisomerase IIβ expression in SH-SY5Y cells during neuronal differentiation.Statins in anthracycline-induced cardiotoxicity: Rac and Rho, and the heartbreakers.C-terminal regions of topoisomerase IIalpha and IIbeta determine isoform-specific functioning of the enzymes in vivo.Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint.Effect of CD26/dipeptidyl peptidase IV on Jurkat sensitivity to G2/M arrest induced by topoisomerase II inhibitors.Ectopic expression of human topoisomerase IIalpha fragments and etoposide resistance in mammalian cells.Role of Topoisomerases in Pediatric High Grade Osteosarcomas: TOP2A Gene Is One of the Unique Molecular Biomarkers of Chemoresponse.Potential utility of an expression array signature for predicting anthracycline responsiveness or resistance.Involvement of DNA topoisomerase IIbeta in neuronal differentiation.DNA topoisomerase IIalpha in multiple myeloma: a marker of cell proliferation and not drug resistance.Topoisomerase IIalpha expression in mantle cell lymphoma: a marker of cell proliferation and a prognostic factor for clinical outcome.Physiological Roles of DNA Double-Strand Breaks.Expression of Topoisomerase II-α protein in salivary gland tumors.Eukaryotic DNA topoisomerase II beta.High topoisomerase IIalpha expression associates with high proliferation rate and and poor prognosis in oligodendrogliomas.Topoisomerases as anticancer targets.
P2860
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P2860
The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
The distribution and expressio ...... and neoplastic human tissues.
@ast
The distribution and expressio ...... and neoplastic human tissues.
@en
type
label
The distribution and expressio ...... and neoplastic human tissues.
@ast
The distribution and expressio ...... and neoplastic human tissues.
@en
prefLabel
The distribution and expressio ...... and neoplastic human tissues.
@ast
The distribution and expressio ...... and neoplastic human tissues.
@en
P2093
P2860
P356
P1476
The distribution and expressio ...... and neoplastic human tissues.
@en
P2093
Hickson ID
Houlbrook S
P2860
P2888
P304
P356
10.1038/BJC.1997.227
P407
P577
1997-01-01T00:00:00Z
P5875
P6179
1005905325